Inhibitors are compounds capable of blocking the catalytic process. Outline with the use of graphs and equations in illustrating the different modes of action of enzyme inhibitors.
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- What are enzymes? What distinguishes enzymes from regular chemical catalysts? On the specificity of enzyme action, please comment. Which factor accounts for their specificity the most? Describe the enzyme catalysis mechanism.What enzyme kinetic parameters are apparantly impacted by uncompetitive inhibitors? Vmax Km Both Km and Vmax Neither Km nor VmaxAn enzyme catalyzes the following reaction. Which of the following inhibitors would you expect to be competitive inhibitors and which non-competitive inhibitors? Please explain briefly.
- Suggest the possible class of enzyme (or name of enzyme) for each of the enzyme-catalyzed reactions below. Briefly explain your answer.Consider the following data for an enzyme-catalyzedhydrolysis reaction in the presence and absence ofinhibitor I: Using a Michaelis-Menten plot, determine Km for theuninhibited reaction and the inhibited reaction.Explain how the following changes affect the rate of an enzyme-catalyzed reaction in the presence of an uncompetitive inhibitor: (a) increasing the substrate concentration at a constant inhibitor concentration, (b) decreasing the inhibitor concentration at a constant substrate concentration.
- Compare the KM and Vmax of the enzyme in the absence and presence of inhibitors to determine what type of inhibitors are compounds Y and Z. Explain your answers.Give the systematic names and the first three digits in the E.C. classifications of the enzymes catalysing the following reactions:Identify the enzymes in Table, whose catalytic effi ciencies are near the diff usion-controlled limit.
- Several factors contribute to enzyme catalysis. What arethey? Briefly explain the effect of each.Several names are compatible with standard nomenclature for the enzyme that catalyzes the reaction shown in the figure. However, the assigned name is based specifically based on its substrate and its coenzyme. What is that name?Sketch the complete reaction free energy diagram for an enzyme-catalyzed conversion of a single substrate (S) into product (P), where the reaction is spontaneous in the forward direction Overlay the free energy diagram for the uncatalyzed reaction and indicate delta delta G〒 on your sketch: Chemical step is rate limiting