Introduction: There’s quite a bit of interest around repurposing extant drugs to treat infections by targeting host pathways that pathogens rely on. Here are a few potential drugs: 1) A drug that inhibits endocytosis, but not phagocytosis. 2) A drug that inhibits degradation of cytoplasmic proteins into smaller peptides, preventing their cycling back into amino acids. 3) A drug used to treat porphyria that reduces the reactivity of heme. 4) A drug that depletes glutathione, a chemical which protects red blood cells against the reactivity of heme. 5) A drug that reduces expression of the ACE-2 protein. Question: Pick a drug and an infection that the drug is likely to be good at treating, or pick an infection and a drug that would most likely make the infection substantially worse. Which drug and pathogen did you pick? Do you think it’ll make it better or worse?
Introduction: There’s quite a bit of interest around repurposing extant drugs to treat infections by targeting host pathways that pathogens rely on. Here are a few potential drugs:
1) A drug that inhibits endocytosis, but not phagocytosis. 2) A drug that inhibits degradation of cytoplasmic proteins into smaller peptides, preventing their cycling back into amino acids. 3) A drug used to treat porphyria that reduces the reactivity of heme. 4) A drug that depletes glutathione, a chemical which protects red blood cells against the reactivity of heme. 5) A drug that reduces expression of the ACE-2 protein.
Question: Pick a drug and an infection that the drug is likely to be good at treating, or pick an infection and a drug that would most likely make the infection substantially worse. Which drug and pathogen did you pick? Do you think it’ll make it better or worse?
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