Lysozyme is an enzyme that hydrolyzes bacterial cell wall polysaccharides. When this reaction is carried out in the presence of H218O, it is observed that there is retention of configuration at the C1 carbon of the D site sugar as shown below Two key amino acid side chains (an Asp and a Glu) essential for lysozyme’s catalytic activity are positioned above and below the C1-O bond that is cleaved as shown below. Suggest a plausible mechanism for the reaction that starts with a nucleophilic attack at C1.
Lysozyme is an enzyme that hydrolyzes bacterial cell wall polysaccharides. When
this reaction is carried out in the presence of H218O, it is observed that there is
retention of configuration at the C1 carbon of the D site sugar as shown below
Two key amino acid side chains (an Asp and a Glu) essential for lysozyme’s
catalytic activity are positioned above and below the C1-O bond that is
cleaved as shown below. Suggest a plausible mechanism for the reaction that
starts with a nucleophilic attack at C1.
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Is the NAM in the explanation supposed to be NAG as shown above in the illustration?
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