It is observed that as temperature is increased, most protein molecules gofrom their defined, folded state into a random-coil, denatured state thatexposes more hydrophobic surface area than is exposed in the folded state.(a) Given what you have learned so far about ΔH and ΔS, explain why thisis reasonable. (b) Sometimes, however, proteins denature as temperature is decreased.How might this be explained?

Biology (MindTap Course List)
11th Edition
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Chapter3: The Chemistry Of Life: Organic Compounds
Section: Chapter Questions
Problem 9TYU: Which of the following levels of protein structure may be affected by hydrogen bonding? (a) primary...
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It is observed that as temperature is increased, most protein molecules go
from their defined, folded state into a random-coil, denatured state that
exposes more hydrophobic surface area than is exposed in the folded state.
(a) Given what you have learned so far about ΔH and ΔS, explain why this
is reasonable. 
(b) Sometimes, however, proteins denature as temperature is decreased.
How might this be explained?

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