Kumada Coupling: Propylbenzene could hypothetically be synthesized by Friedel-Crafts alkylation. However, this reaction is not practical. What is the problem with synthesizing propylbenzene by Friedel-Crafts alkylation? 1. 2. 3. Propose a synthesis of propylbenzene from benzene and any other reagents you need using reactions from 351/352 lecture that does NOT use a coupling reaction. How would you prepare the following molecule using a Kumada coupling?

Organic Chemistry: A Guided Inquiry
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ISBN:9780618974122
Author:Andrei Straumanis
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Chapter13: Substitution
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Kumada Coupling:
1. Propylbenzene could hypothetically be synthesized by Friedel-Crafts alkylation. However, this reaction is
not practical. What is the problem with synthesizing propylbenzene by Friedel-Crafts alkylation?
2.
3.
Propose a synthesis of propylbenzene from benzene and any other reagents you need using reactions from
351/352 lecture that does NOT use a coupling reaction.
How would you prepare the following molecule using a Kumada coupling?
Transcribed Image Text:Kumada Coupling: 1. Propylbenzene could hypothetically be synthesized by Friedel-Crafts alkylation. However, this reaction is not practical. What is the problem with synthesizing propylbenzene by Friedel-Crafts alkylation? 2. 3. Propose a synthesis of propylbenzene from benzene and any other reagents you need using reactions from 351/352 lecture that does NOT use a coupling reaction. How would you prepare the following molecule using a Kumada coupling?
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