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Using appropriate diagrams explain the LD50 of a toxin and describe how you will calculate the LD50 from a dose-response curve?
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- Why are animals used in laboratory experiments in toxicology? Explain the dose-response curve. Why is a substance with a high LD50 considered safer than one with a low LD50?In the double-reciprocal plot, increasing the concentration of inhibitor A. raises the Vmax. B. lowers the Km / Vmax. C. raises the Km / Vmax. D. lowers the Km.Draw a dose response curve that shows a logarithmic response that leads to saturation. Be sure to label the x and y axis
- Would the same procedure done in Minimum Inhibitory Concentration (MIC) be applicable in determining allergies in man?How would a dose-response relationship affects toxicity?How is the concept of dose-response related to the following statement by Paracelsus: “All substances are poisonous, there are none that are not. The correct dose differentiates a poison from a remedy ”? (Present a graph and use it to build your answer)
- Explain the role of LC50 in ensuring the safety of a drug candidate? Explain at your own wordsWhat knowledge can be gained from dose-response relationships? Why are the shape and slope of a dose-response curve important? What role do shape and slope play in environmental toxicology?The following dose-response curve depicts the physiological response to a drug or combination of drugs as a function of agonist concentration. First, post an explanation of the different curves noted in regards to the type of each drug administered. There may be more than one answer.
- Plot the dose response curve and find what the slope factor for a human. Determine the concentration in drinking water that will give a 10^-4 risk for human population assuming lifetime ingestion. The weight of the female mice is 0.05 kg.If drug X has an ED50 of 10 and LD50 of 50. Drug Y has an ED50 of 10 and LD50 of 100. Which of the following statement is correct? A.Drug X is safer than drug Y B.Drug Y is safer than drug X. C.Drug X is more potent than drug Y D.Drug Y is more potent than drug X E.Drug X is less potent than drug YIf an elderly person has less protein in the blood than a younger person, how would you adjust the dose of a drug that has high protein binding?