Time-release” drugs work by releasing a drug to the body at a constant rate such that the drug concentration at one time is not large enough as to cause harmful side effects OR not low enough to the point where it is an ineffective therapeutic. A design schematic of a time-release pill is shown below. Explain how it works from an osmotic pressure standpoint.

Here’s the fractional binding data for 2 different proteins (1 and 2) binding to a Drug D. Which of the following statements is/are true?     1 of 5: Each Protein 1 must only bind 1 molecule of D. 2 of 5: Each Protein 2 must bind 2 or more molecules of D. 3 of 5: Protein 2 binds significantly more D than Protein 1. 4 of 5: Protein 1 and 2 have roughly similar binding affinities for D. 5 of 5: Protein 1 binds faster to D than protein 2 does at low concentrations of D.

A nurse is caring for a client who has a prescription for 5 units of regular insulin and 10 units of NPH Insulin to mix together and administer subcutaneously. Determine the correct order of steps for this procedure. Move the steps into the box on the right, placing them in the order of performance. Use all the steps.) fonts of air to the bottle of regular in wdraw the correct dose of insulin from the back jest to units of ar into the battle of NPH insulin Withdraw the correct dise of regular insulin from the bottle

Give typed solution with explanation The nurse receives a dose range prescription for a child who weighs 62lbs. The recommended dose range is between 20-35 mg/kg//dose every 4-6 hours. calculate the dose range. Round the mg dose range answers to the hundredth.

Write a brief note of an ACE inhibitor?  Please write at your own words.

What is the purpose of a closure? What are the characteristics of good closure? [Pharmaceutical products closure ] Please explain at your own words.

In the design of H2 antagonists, the polar guanidine group of compound A was proposed to interact with the antagonist binding region by two hydrogen bonds. This compelled researchers to derivatize compound B from compound A. HN EN Chain Extension Rigidification ZI compound A What drug design strategy has been used here? Simplification H₂N NH Substituent variation HN NH₂ HN NH N compound B

A dose-limiting toxicity is: to A. B. a severe side effect that a patient cannot tolerate without life threatening risks. C. the total dose of a drug given throughout a cycle of treatment. D. a known and expected side effect that is unwanted and unpleasant. the total amount of a specific drug that is safely given over a patient's lifetime.