Answered: Like acid chlorides, acid anhydrides…

Like acid chlorides, acid anhydrides react with alcohols in the presence of pyridine to form esters. For the following reaction

Macroscale and Microscale Organic Experiments

7th Edition

ISBN:9781305577190

Author:Kenneth L. Williamson, Katherine M. Masters

Publisher:Kenneth L. Williamson, Katherine M. Masters

Chapter32: Friedel-crafts Acylation Of Ferrocene: Acetylferrocene

Section: Chapter Questions

Problem 1Q

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Question

Like acid chlorides, acid anhydrides react with alcohols in the presence of pyridine to form esters. For the following reaction : (a) Draw a circle around the nucleophile ; (b) Draw a square around the electrophile; (c) Put a star next to the base; (d) Draw the structure of the tetrahedral intermediate in the box below. Then draw a reasonable 3-step arrow pushing mechanism for the reaction.

bo
pyridine
HO
Structure of tetrahedral intermediate

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