Answered: LINEAR GROWTH LATERAL ASSOCIATION…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter28: Dna Metabolism: Replication, Recombination, And Repair

Section: Chapter Questions

Problem 12P

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Question

A solution of pure αβ-tubulin dimers is thought to
nucleate microtubules by forming a linear protofilament
about seven dimers in length. At that point, the probabili-
ties that the next αβ-dimer will bind laterally or to the end
of the protofilament are about equal. The critical event
for microtubule formation is thought to be the first lateral
association (Figure Q16–2). How does lateral association
promote the subsequent rapid formation of a microtu-
bule?

LINEAR GROWTH
LATERAL ASSOCIATION
Figure Q16-2 Model for microtubule nucleation by pure aß-tubulin
dimers (Problem 16-7).
0000

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