Make Your Own Pedigree First, choose a trait that you would like to investigate. It should be a heritable trait like tongue rolling, cleft chin, widow’s peak, opposable thumb, or hand clasping. Then, interview or observe the trait starting with your grandparents (mother or father side). This will be followed by your aunts and uncles, and for the third generation you, your siblings, and your cousins. Draw your pedigree on the space provided
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II. Make Your Own Pedigree
First, choose a trait that you would like to investigate. It should be a heritable
trait like tongue rolling, cleft chin, widow’s peak, opposable thumb, or hand clasping.
Then, interview or observe the trait starting with your grandparents (mother or father
side). This will be followed by your aunts and uncles, and for the third generation you,
your siblings, and your cousins. Draw your pedigree on the space provided
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- 1. Construct a pedigree chart of the trait traced in the situation below.2. The pedigree chart must be constructed with the names and genotypes at the bottom of every individual in the chart.If it is autosomal: Always use the first letter of the dominant trait to represent the dominant allele. For example, if the dominant trait is red, so the allele R-red, while r-yellow. For example, if the person is homozygous dominant for curly hair, we write CC as his genotype. If sex-linked, do not forget to write the parents’ chromosomes (XX-female, XY-male), with their corresponding superscripts (dominant or recessive). The superscript must be based on the first letter of the disorder. For example, the mother is a carrier of hemophilia (which is x-linked recessive), so we write XHXh. If the father has hemophilia, we write XhY. Put the pedigree chart using code properly. The situation is given below: Trait: NeurofibromatosisThe dominant form is neurofibromatosis, caused by the production of…1. Construct a pedigree chart of the trait traced in the situation below.2. The pedigree chart must be constructed with the names and genotypes at the bottom of every individual in the chart.If it is autosomal: Always use the first letter of the dominant trait to represent the dominant allele. For example, if the dominant trait is red, so the allele R-red, while r-yellow. For example, if the person is homozygous dominant for curly hair, we write CC as his genotype. If sex-linked, do not forget to write the parents’ chromosomes (XX-female, XY-male), with their corresponding superscripts (dominant or recessive). The superscript must be based on the first letter of the disorder. For example, the mother is a carrier of hemophilia (which is x-linked recessive), so we write XHXh. If the father has hemophilia, we write XhY. Put the pedigree chart using code properly. The situation is given below: Trait: NeurofibromatosisThe dominant form is neurofibromatosis, caused by the production of…Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?
- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?SCIENCE, TECHNOLOGY, AND SOCIETY Imagine that you are a genetic counselor. What advice or suggestions might you give in the following situations? (a) A couple has come for advice because the woman had a sister who died of Tay-Sachs disease. (b) A young man and woman who are not related are engaged to be married. However, they have learned that the mans parents are first cousins, and they are worried about the possibility of increased risk of genetic defects in their own children. (c) A young womans paternal uncle (her fathers brother) has hemophilia A. Her father is free of the disease, and there has never been a case of hemophilia A in her mothers family. Should she be concerned about the possibility of hemophilia A in her own children? (d) A 20-year-old man is seeking counseling because his father was recently diagnosed with Huntingtons disease. (e) A 45-year-old woman has just been diagnosed with Huntingtons disease. She says she will not tell her college-age sons because of the burden it will place on them. Given that the woman, not her sons, is your client, do you have a duty to inform the sons? Explain your reasoning.
- PKU is a recessive disorder based on a single mutant gene. Consider that Noor is a carrier, but her partner Hamza has never had an incidence of PKU show up in his family history, which dates back to four generations. What is the likelihood their first child might develop PKU according to their genetics counselor? a) 100%! b) 50% c) 25% d) 0%Color blindness is typically an inherited genetic condition in which individuals have a decreased ability to see color or differences in color. Color blindness only occurs in individuals who have two recessive alleles for the condition. Normal color vision is due to a dominant allele (C) Color blindness is due to the recessive allele (c) a) If Susan is homozygous for normal vision, and Matt is homozygous for color blindness, what is the likelihood (in percentage) that their son Alex will have color blindness? Perform a Punnett Square (either below or by hand on paper) to find the probability. Provide your answer in a full sentence. If you did the Punnett Square by hand, attach your photo to the next question.1-Pedigrees exhibiting consanguinity, show increased presence of _________ traits? a-Dominant Traits b-Recessive Traits c-X-linked Traits d-Disease Traits
- Imagine that you are a genetic counselor, and a couple planning to start a family comes to you for information. Charles wasmarried once before, and he and his first wife had a child withcystic fibrosis. The brother of his current wife, Elaine, died ofcystic fibrosis. What is the probability that Charles and Elainewill have a baby with cystic fibrosis? (Neither Charles, Elaine,nor their parents have cystic fibrosis.)Solve the following genetics problem: (1)Assume that you are a lawyer working in a family law and divorce practice. Your client, a lady that just had a child, is seeking financial support from her millionaire ex-boyfriend. The medical records that was provided are the following: (A) Your client's blood type is O . (B) The alleged father of the child blood type is AB positive. (C) The child's blood type is O. While conferring with your client you advise her the following ...Explain your answer using Mendelian Genetics language. ...INTRODUCTION: Pedigrees are symbolic representations of family relationships and the transmission of inherited traits. For researchers, families are tools; the bigger the family, the easier it is to discern modes of inheritance. Pedigrees apply Mendel’s laws to predict the recurrence risks of inherited conditions. INSTRUCTION: Discuss the pedigree using appropriate terms.