Remember the following when working pedigree tables:1) Circles are females and squares are males.2) A shaded circle or square indicates that a person has the trait.The pedigree seen below is for colorblindness. Shaded individuals are colorblind. Determine theprobable genotype of persons 1-15, and then answer the questions below the table.26.101112131415How did you determine the genotype of the mother at 37Number 8 was colorblind just like his father. Where did the son at 8 get his allele for colorblindness?Neither numbers 1 nor 2 were colorblind. How did they have a colorblind son (6)7What must be the genotypes of the parents of a colorblind daughter? Explain.If number 13 marries a normal man, what is the probability that their sons will be colorblind?

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Description: Remember the following when working pedigree tables:1) Circles are females and squares are males.2) A shaded circle or square indicates that a person has the trait.The pedigree seen below is for colorblindness. Shaded individuals are colorblind. Det

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Remember the following when working pedigree tables: 1) Circles are females and squares are males. 2) A shaded circle or square indicates that a person has the trait. The pedigree seen below is for colorblindness. Shaded individuals are colorblind. Determine the probable genotype of persons 1-15, and then answer the questions below the table. 2 6. 8. 9 10 12 13 14 15 How did you determine the genotype of the muther at 37 Number 8 was colorblind just like his father. Where did the son at 8 get his allele for colorblindness? Neither numbers 1 nor 2 were colorblind. How did they have a colorblind son (6)? C0

Remember the following when working pedigree tables: 1) Circles are females and squares are males. 2) A shaded circle or square indicates that a person has the trait. The pedigree seen below is for colorblindness. Shaded individuals are colorblind. Determine the probable genotype of persons 1-15, and then answer the questions below the table. 2 6. 8. 9 10 12 13 14 15 How did you determine the genotype of the muther at 37 Number 8 was colorblind just like his father. Where did the son at 8 get his allele for colorblindness? Neither numbers 1 nor 2 were colorblind. How did they have a colorblind son (6)? C0

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter15: Genomes And Genomics

Section: Chapter Questions

Problem 2QP: Hemophilia and color blindness are both recessive conditions caused by genes on the X chromosome. To...

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Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?
Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?
Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?
Hemophilia and color blindness are both recessive conditions caused by genes on the X chromosome. To calculate the recombination frequency between the two genes, you draw a large number of pedigrees that include grandfathers with both hemophilia and color blindness, their daughters (who presumably have one chromosome with two normal alleles and one chromosome with two mutant alleles), and the daughters sons. Analyzing all the pedigrees together shows that 25 grandsons have both color blindness and hemophilia, 24 have neither of the traits, 1 has color blindness only, and 1 has hemophilia only. How many centimorgans (map units) separate the hemophilia locus from the locus for color blindness?
A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known concordance statistics, would his MZ twin be at high risk for the disease? Would the twins risk decrease if he were raised in an environment different from that of his schizophrenic brother?
As it turned out, one of the tallest Potsdam Guards had an unquenchable attraction to short women. During his tenure as guard, he had numerous clandestine affairs. In each case, children resulted. Subsequently, some of the childrenwho had no way of knowing that they were relatedmarried and had children of their own. Assume that two pairs of genes determine height. The genotype of the 7-foot-tall Potsdam Guard was A9A9B9B9, and the genotype of all of his 5-foot clandestine lovers was AABB. An A9 or B9 allele in the offspring each adds 6 inches to the base height of 5 feet conferred by the AABB genotype. a. What were the genotypes and phenotypes of all the F1 children? b. Diagram the cross between the F1 offspring, and give all possible genotypes and phenotypes of the F2 progeny
Given the pedigree below: Is the trait dominant or recessive? What are the most likely genotypes of individuals I-1 and I-2? What is the probability that individual II-2 is a carrier?
Given the following pedigree: Is the trait autosomal or sex-linked? Is the trait dominant or recessive? Based only on the information given, what is the probability that I-2 is heterozygous? Give the genotypes of individuals II-3, II-4. What is the probability that individual III-1 is purebreeding?
In pedigrees, individuals are usually specified by using a Roman numeral for their generation in the chart and an Arabic number for their position (reading left to right) within that generation. If we use the letter c for the allele that causes cystic fibrosis, what are the genotypes of individuals III-3 and III-4 (the third and fourth individuals shown in generation III) in the pedigree that shows this disease?
What could be the genotypic and phenotypic ratios for a typical mendelian trait showed in the picture?
Consider the two traits: Blood Type B (Parents and Child with Blood Type B, Grandparents unknown) and Hanging Earlobe (Parents and Child with Blood Type B, Grandparents unknown). From this, create a 3-generation pedigree chart (starting from grandparents' generation).What is a possible analysis regarding the mode of inheritance of the observed traits?
Using the pedigree below, determine whether the alleles B or C have a dominant or recessive relationship, which allele is dominant, and the genotype for individuals I-1, I-2, I-3, I-4, II-4, and II-5. Use B or C for the alleles and X for unknown alleles. Note: White squares/circle indicate normal phenotypes. Dark squares/circles indicate the individual has the condition. The B allele is associated with the condition. Label the pedigree chart with genotypes as needed.