Male with a history of blistering lesions on the scalp since the neonatal period and recurrent pyoderma. After a year and a half of life, he was admitted to a specialty clinic due to generalized pyoderma associated with febrile illness with lymphadenopathies and abscesses on the thighs. To the physical examination revealed coarse facies, broad forehead, infraorbital fold, presence of dark circles, low nasal bridge and hypertelorism. In addition to confluent maculopapular lesions in the neck and trunk, occipital eczema, genital gluteal hyperchromic plaque, purulent external otitis. it was tried with antibiotics with good response, but with persistence of purulent otorrhea. The study of serum immunoglobulins IgM, IgG, IgA, complement, chemotaxis and burst Respiratory was within normal ranges. Serum IgE stood out at 56,400 IU/ml (range normal for age 0-90 IU/ml) and eosinophilia. At the age of 2 years 11 months he was hospitalized for genital phlegmon with a good response to cloxacillin plus cefotaxime iv. In subsequent check-ups, it evolved with pruritus, patchiness and Difficult to manage generalized vulgar warts. At the age of 6, he was hospitalized again. due to generalized impetigo with positive culture for S. aureus and ear discharge culture positive for Pseudomonas. 1- What would be the patient's diagnosis? Could it be Osteogenesis Imperfecta? If it is explain why your conclusion. 2- What justifies your diagnosis? Tests or labs? 3- What are the characteristics of this disease? 4- What diagnoses could this be confused with? 5- What is the prognosis of the patient's life? 6- What treatments would be indicated to the patient?
Male with a history of blistering lesions on the scalp since the neonatal period and
recurrent pyoderma. After a year and a half of life, he was admitted to a specialty clinic due to
generalized pyoderma associated with febrile illness with lymphadenopathies and abscesses on the thighs. To the
physical examination revealed coarse facies, broad forehead, infraorbital fold, presence of dark circles,
low nasal bridge and hypertelorism. In addition to confluent maculopapular lesions in the neck
and trunk, occipital eczema, genital gluteal hyperchromic plaque, purulent external otitis. it was tried
with antibiotics with good response, but with persistence of purulent otorrhea.
The study of serum immunoglobulins IgM, IgG, IgA, complement,
Respiratory was within normal ranges. Serum IgE stood out at 56,400 IU/ml (range
normal for age 0-90 IU/ml) and eosinophilia.
At the age of 2 years 11 months he was hospitalized for genital phlegmon with a good response to
cloxacillin plus cefotaxime iv. In subsequent check-ups, it evolved with pruritus, patchiness and
Difficult to manage generalized vulgar warts. At the age of 6, he was hospitalized again.
due to generalized impetigo with positive culture for S. aureus and ear discharge culture
positive for Pseudomonas.
1- What would be the patient's diagnosis? Could it be Osteogenesis Imperfecta? If it is
explain why your conclusion.
2- What justifies your diagnosis? Tests or labs?
3- What are the characteristics of this disease?
4- What diagnoses could this be confused with?
5- What is the prognosis of the patient's life?
6- What treatments would be indicated to the patient?
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