Match each of the changes that can contribute to cancer with its correct description. Loss of function of regulators that send old or damaged cells into apoptosis Hyperactivation of signalling pathways that tell the cell to grow and divide 1. Sustaining proliferative signalling Loss of function of structural proteins that anchor cells to surrounding tissue and/or activation of cell migration 2. Evading growth suppressors 3. Activating invasion and metastasis Loss of function of 4. Enabling replicative immortality regulators that stop inappropriate growth and cell division 5. Inducing angiogenesis 6. Resisting cell death Loss of function of regulators that force aging cells to exit the cell cycle and enter GO or replicative senescence

Match each of the changes that can contribute to cancer with its correct description. Loss of function of regulators that send old or damaged cells into apoptosis Hyperactivation of signalling pathways that tell the cell to grow and divide 1. Sustaining proliferative signalling Loss of function of structural proteins that anchor cells to surrounding tissue and/or activation of cell migration 2. Evading growth suppressors 3. Activating invasion and metastasis Loss of function of 4. Enabling replicative immortality regulators that stop inappropriate growth and cell division 5. Inducing angiogenesis 6. Resisting cell death Loss of function of regulators that force aging cells to exit the cell cycle and enter GO or replicative senescence

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section: Chapter Questions

Problem 7QP

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Similar questions

What is the significance of studying cell movement, particulary the epithelial-to-mesenchymal transition, in the study of cancer?
''Cancer therapies directed solely at killing the rap-idly dividing cells that make up the bulk of a tumor areunlikely to eliminate the cancer from many patients.'' Is this statement true? Explain why or why not.
Define E-cadherin activity is lostduring the epithelial-to-mesenchymal transition and during cancerprogression.
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With regard to cancer cells, which of the following statementsare true?A. Cancer cells are clonal, which means they are derived from asingle mutant cell.B. To become cancerous, cells usually accumulate multiplegenetic changes that eventually result in uncontrolledgrowth.C. Most cancers are caused by oncogenic viruses.D. Cancer cells have lost the ability to properly regulate celldivision.
A genetic predisposition to developing cancer is usually inheritedas a dominant trait. At the level of cellular function, are the allelesinvolved actually dominant? Explain why some individuals whohave inherited these dominant alleles do not develop cancer duringtheir lifetimes.
Out of these 8 hallmarks ( sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, deregulating cellular energetics and metabolism, and avoiding immune destruction). Rank them from least important to most for cancer development. Explain in 2-3 sentences how.
Which of the following are mechanisms by which cancer drugs work (select all that apply)? A. Inhibit activity of oncogene B. Promote apoptosis C. Promote terminal differentiation of cells D. Inhibit drug transporters E. Promote DNA damage.
Whether the statement "Cancer therapies directed solely at killing the rapidly dividing cells that make up the bulk of a tumor are unlikely to eliminate the cancer from many patients" is true or false.
Cancer is related to cellular errors during certain mechanisms and due to certain factors yet, the rate of cancer in cells is low. Describe how cells maintain themselves away from getting cancerous. Give molecular evidences where necessary.