Cell Signalling. Use the topic and relate the topic for initiation, progression and invasion-metastasis of cancer. You may choose any cancer type.
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Q: Give the pathway-disruption in the pathway of apoptosis, how this can lead to different diseases?
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Q: Explain the role of p53 protein in protecting normal cells against cancer. With respect to this…
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Q: Please explain correct answer
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Cell Signalling. Use the topic and relate the topic for initiation, progression and invasion-metastasis of cancer. You may choose any cancer type. Please make sure that you prepare the paper with your own word.
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- Heterotypic interactions of tumor cells have been a fertile area for potential therapeutic interventions. Find a specific example of a drug/therapy that targets these interactions and explain the mechanism by which it treats cancer.Clinical trials to prevent activation and invasion of cancer metastasis, explain where they are in the trial and why they may or may not work etc..Explain the mechanism of these in cancer treatment, all details needed. no details no rate.
- Need detail explanation Scenario: A 56-year-old client was diagnosed with aggressive bone cancer that required a below the knee amputation of the left leg 14 months ago. The client received recommended chemotherapy and radiation, but it was found recently that the cancer has metastasized to the chest and skull. There is lymph node involvement with a primary tumor partially obstructing the right kidney. The client was readmitted 4 days ago for removal of the remaining portion of the left leg and was told that there is no appropriate surgical or medical intervention that would be beneficial at this point in the disease process. The interdisciplinary health care team has recommended palliative care upon discharge since the client’s life expectancy is between 3 and 5 months. The client has developed a mutually respectful relationship with a nurse on the unit who has provided care throughout all previous hospitalizations. The client shares with the licensed practical nurse (LPN) that, “I…True/False with Justification. Indicate whether the statement is true or false. Then, regardless of whether you choose true or false, explain your reasoning. The Wee1 kinase could be considered the product of a tumor suppressor gene. A cell containing a mutant form of the Rb protein that cannot be phosphorylated would be blocked at the G1 -> S checkpoint.advantages and limitations of circulating tumor dna as biomarkers for cancer detection
- “Disruption in the pathway of apoptosis & autophagy can lead to different diseases”- Briefly explain that statement at your own words?Give the pathway-disruption in the pathway of apoptosis, how this can lead to different diseases?CASE STUDY Cancer-killing bacteria Ralph, a 57-year-old man, was diagnosed with colon cancer.His oncologist discussed the use of radiation andchemotherapy as treatments, both of which can causedebilitating side effects. Ralph decided to explore other optionsand went to a cancer clinic. He learned that researchers in asynthetic biology program were testing the use of geneticallymodified bacterial cells designed to selectively invade specifictumors and kill cancer cells, with no effects on normal cells.Ralph decided to participate and was informed that he wouldbe part of a phase III trial, comparing the effects of the modifiedbacterial cell treatment against conventional chemotherapy.However, as part of the trial, he would be randomly assigned toreceive one or the other treatment. He was disappointed to learnthis, because he assumed that he would receive the bacterialtherapy.Question: Informed consent is legally and ethically required beforesomeone participates in a clinical trial.…
- Explain the role of p53 protein in protecting normal cells against cancer. With respect to this protein and its function, explain how a normal cell turns cancerous.true or false? And why it is false For the actin cytoskeleton, diverse cell-surface receptors trigger global structural rearrangements in response to external signals. But all these signals seem to converge inside the cell on a group of closely related monomeric GTPases that are members of the Rho protein family—Cdc42, Ras, and Rho. The same Rho family proteins are also involved in the establishment of many kinds of cell polarity.Genetic instability in the form of point mutations, chromosome rearrangements, and epigenetic changes needs to be maximal to allow the development of cancer. (a) With diagrams explain point mutations