Mechanism. Studies have shown that aldol condensation can be catalyzed by amines via an enamine intermediate. Propose a mechanism for the following reaction, as catalyzed by lysine. R NH2 OH catalytic lysine group H. H20, pH = 4 - 5

Q: Below is one of the reactions used in the synthesis of eluxadoline. What type of reaction is it?…

A: Reductive amination

Q: The intramolecular Aldol condensation of 2,6-heptanedione with basc may produces two possible…

A: Intramolecular reaction means within the molecule the reaction takes place. In Aldol reaction,…

Q: Mechanism. Studies have shown that aldol condensation can be catalyzed Propose a mechanism for the…

A: Various synthesis reactions are studied in organic chemistry. Aldol condensation is one of them. It…

Q: Compound 5 (shown below) displays intriguing reactivity features at distinct pHs. We will explore…

A: (a) In highly basic condition, the following mechanism can take place

Q: Q/ Give the product for the following reactions: OH (1)Acetone + acetaldehyde OH (2)2 Acetone ? Q/…

A: The reaction which is occur between the enolate ion and the carbonyl compound is known as aldol…

Q: Propose a mechanism for the base-catalyzed aldol condensation of acetone (Figure 22-2).S

A:

Q: Melting Point Range Identity of Aldehyde Identity of Ketone 179-181 C Cinnamaldehyde Cyclohexanone

A:

Q: CH3 N. CH3 Но Ph

A: For retrosynthetic analysis one has to identify the compound, should have the knowledge of…

Q: Propose a mechanism for this acid-catalyzed aldol reaction and the dehydration of the resulting…

A: Given: The reaction mechanism for the acid-catalyzed Aldol reaction followed by the dehydration of…

Q: In the Gabriel synthesis of primary amines, N-potassiophthalimide is used as a source of the…

A: This is a Gabriel phthalamide synthesis reaction. Through this reaction 1° amine is produced by the…

Q: Draw the structure of the major aldol product (prior to possible dehydration) of the following…

A: In both of the above equations, we have to write down the structure of the major aldol product…

Q: The intramolecular Aldol condensation of 2,6-heptanedione with base may produces two possible…

A:

Q: Show how the following synthesis could be carried out. More than one step is required. он „CN (+…

A: We will write the conversion

Q: 2. a. Provide mechanisms and/or products for the following transformation. NE2 `Me (-5 equiv) H Me…

A: Reaction 1 : Acid catalyzed enamine synthesis followed by Diels Alder reaction.

Q: Part of Percy Julian's synthesis of physostigmine is shown below. Which set of reagents could…

A:

Q: Нet CH20 H Но НО H2N Acid Ar Ar Ar Ar G F J Treatment of amine G with formaldehyde generated iminium…

A: The above reaction proceeds via imine Formation. And rearrangement simultaneously.

Q: DCC= diaydonexylcarbodimide Ester Yormation RxN DCC HO OH

A: Here is  the mechanism of the ester formation

Q: d. (i) Discuss the mechanism of the reaction sequence shown in Scheme 1, include all curly arrows in…

A:

Q: Propose a mechanism for the following transformation: Et Me он 1) Excess EtMgBr 2) H30* Me "CI 'Et

A: Three membered rings formed by two carbon and one oxygen atom is known as an epoxide ring. The…

Q: Co2 + catalyzes the hydrolysis of the lactam shown here. Propose a mechanism for the metal-ion…

A:

Q: 4. Here's a figure-it-out mechanism, resulting in the formation of p-aminophenol from an aromatic…

A: Introduction: The formation of para-aminophenol takes place through N-phenyl hydroxylamine. The…

Q: Which of the following is a major product of the reaction sequence shown in the box? NABH4 HCI, H20…

A: Organic reactions are those in which organic reactant react to form organic products.

Q: 3. Show the mechanism for the acid catalyzed addition of H2O to the following ketone. OH H20 CH3 H*

A:

Q: The following reaction occurs through an Elcb mechanism followed by a tautomerization. Provide a…

A: E1CB is a two step reaction in which the intermediate formed is a carbanion and is one of the…

Q: NaOEt, A Ph Ph. H20 N. ОН

A:

Q: Show how to synthesize the following compound  using either the malonic ester synthesis or the…

A: We can use the malonic ester synthesis pathway to get Cyclobutyl methyl ketone. The synthesis…

Q: Show the products of the following reactions: (a) CH3CH2CH2NH2 + CH3Br (b) Cyclohexylamine + HBr (c)…

A: The reactions are given below

Q: Suggest starting materials for the formation of the following aldol products: (a) (b) O I `H H

A: Aldol condensation: The alpha hydrogen of carbonyl compounds is acidic in nature and it is removed…

Q: 1. Convert following retrosynthesis to synthesis (give all necessary steps, reagents and products…

A: Since you have posted multiple questions, we will answer the first one for you. To get the remaining…

Q: 21) Propose a mechanism for the following reaction. OH H2O, H*

A: Alkenes undergo addition reactions in presence of water and acid. The reaction proceeds via the…

Q: Below is one of the steps in the synthesis. What type of reaction is it? Br , AICI, он Niraparib •…

A: Friedel Crafts acylation

Q: 18. Show the mechanism of the following reaction: butanyl chloride hexanone 3-ethylhexan-3-ol

A:

Q: Show how to synthesize the following compound  using either the malonic ester synthesis or the…

A: The malonic ester synthesis of 2-Propyl-1,3-propanediol undergoes a nuclophilic attack using strong…

Q: a) Give a curved arrow-pushing mechanism for the following reactions. 1) NaOHag 2) Cl2 ola CH3 CH3 +…

A: Hello. Since your question has multiple parts, we will solve the first question for you. If you want…

Q: Show how you would synthesize 2-phenylethanamine (PHCH2CH2NH2) starting from the following reagents.…

A: In this question, we want to Synthesized the PhCH2CH2NH2 from the starting material ( which have…

Q: Identify the MAJOR product(s) that would be obtained from the following reaction sequence (i.e. not…

A: Hofmann elimination is an amine elimination reaction that produces the Hofmann product, which is the…

Q: An amide with an NH2 group can be dehydrated to a nitrile with thionyl chloride (SOCl2). Propose a…

A: Thionyl chloride when reacts with 1° amide, a nitrile can be produced. A four step mechanism can be…

Q: 25. Provide the reagents necessary for the following transformation. OH ??? CI А. SOCI2, pyridine В.…

A: To find: reagent used to transform 2-methylhexan-2-ol to 2-chloro-2-methylhexane.

Q: Propose a mechanism for the following reaction Phố PhCI MegSi- -OMe -OMe

A: The reaction proceeds via a nucleophilic attack of the electron rich benzene ring on the carbonyl…

Q: Propose retrosynthesis and later synthesis COOET EtOOC CH3

A: By retrosynthetic analysis, we actually try to move backwards on the synthetic line and try to reach…

Q: 1. Provide a detailed mechanism for the following reaction and give the structure of the product 1.…

A: This equation contains  multiple Questions so for multiple Questions, I will just give first…

Q: (CH3CH2)2NH, mild acid NABH3CN NaOH, H2O NaOH, H20, heat

A: Arrow  pushing  mechanism

Q: 12) Show how the following synthesis can be carried out: СН3CH2CHCH3 from HCECH Br

A: Since you have asked multiple questions, we will solve the first question for you. If you want any…

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.