Asked Sep 9, 2019

Modification of intregal proteins consequences? 


Expert Answer

Step 1

An integral protein is any protein that has a special functional region for the purpose of securing its position within the cellular membrane. It is permanently attached to the biological membrane.  

Step 2

Proteins are generally modified post-translation, which increases the functional diversity of the proteome by the covalent addition of functional groups or proteins, proteolytic cleavage of regulatory subunits, or degradation of entire proteins. Post-translational protein modifications include phosphorylation, acetylation, acylation, methylation,ubiquitination etc.   

Step 3

Not much is known about the post-translational modification of integral proteins. Integral membrane proteins remain a challenge to proteomics because they contain domains with physicochemical properties poorly suited to today\'s protocols. However, some suggest that modification of integral proteins serve as a means to regulate protein trafficking. Protein acylation alters the tilting of transmembrane proteins with respect to the normal bilayer. Moreover, the proteins\' partitioning behavior and cluster formation ability due to hydrophobic mismatching are also altered signific...

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