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Mutations in the EGF receptor can cause nonstop activation
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- compare and contrast the signaling events involved with the second messanger camp and IP3A scientist observes a mutation in the transmembrane region of EGFR that eliminates its ability to be stabilized by binding interactions during dimerization after ligand binding. Which hypothesis regarding the effect of this mutation on EGF signaling is most likely to be correct? EGF signaling cascades would be active for longer in the cell. EGF signaling cascades would be active for a shorter period of time in the cell. EGF signaling cascades would not occur. EGF signaling would be unaffected.Suppose that you measured binding to the isolated EGF receptor of EGFat various concentrations. Would you expect the binding curve to be hyperbolic? Explain your answer.
- What is the structural difference between normal EGFR and oncogenic receptor, e.g. ERbB? How does it affect its activity?Can you please describe the role of G proteins in ligand-activated cellular signal transduction.In many breast cancers, ER (alpha) activation by estrogens is generally considered responsible for enhanced proliferation, whereas that is counteracted by the presence of ER (beta),which exerts an antiproliferative effect. Please devise a strategy targeting both receptors for the treatment of this disease.
- Which of the following satements are true? Reduction in FGFR signalling leads to achondroplasiaPTCH1 is the receptor for NodalExcessive FGFR signalling leads to achondroplasiaMutations in HOX6 cause aniridiaNone of the other statements are trueG-protein coupled receptors have a GTP-binding domain. True FalseThe two major types of cell-surface receptors that bind tohormone molecules are G-protein linked receptors and_____________________.
