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My sincere apologies for not reading the honor code properly. Can I have an overview of how to construct linkage maps and calculate the interference based on a given table of traits?

Question

My sincere apologies for not reading the honor code properly. Can I have an overview of how to construct linkage maps and calculate the interference based on a given table of traits?

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Step 1

Genetic linkage is explained as the closeness of genes on a chromosome (closely packed DNA molecule) that explains why two genes are inherited together in an individual.

Step 2

Homologous Chromosomes (pair of chromosomes that have similar, centromere location, gene position and length) exchanges their segments during the process of crossing over (occurs during meiosis) and generates recombinant chromosomes. The frequency of formation of recombinant chromosomes depend on the proximity of two genes on a chromosome. If two genes are very closely located, they will be exchanged together and thus defines that higher recombination frequency means that the two genes are not located in proximity. Recombination can occur at single region on a chromosome (known as single crossover or single recombinant), at two region (double crossover or double recombinants) or more than two regions.

Formula to calculate recombinant frequency between genes is as follows:

 

recombinant offspring
Recombination frequency=
total offspring
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recombinant offspring Recombination frequency= total offspring

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Step 3

To determine the relative position (and not physical distance) of genes on a chromosome, linkage map is constructed. It is constructed based on frequency of two genes inheriting together (or frequency of recombination). The distance of genes on a chromosome is calculated in centimorgans (cM) or map unit (m.u.).

In an exper...

6.4 сМ
b c
13.2 сМ/
Gene locus on the
chromosome
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6.4 сМ b c 13.2 сМ/ Gene locus on the chromosome

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