Nucleus Cytoplasm Neuron -PrpSc -PrpC A prion protein in the PrpSc conformation comes in contact with a PrpC protein, converting it into a PrpSc protein. - Original PrpSc molecule -PrpSc converted from PrpC The 2 PrpSc proteins bind to 2 PrpC proteins, and convert them to PrpSc Over time, all of the PrpC proteins will be converted to PrpSc proteins. FIGURE 25.9 A proposed molecular mechanism of prion diseases. The PrPSc protein catalyzes the conver- sion of a PrP protein to PrP8*. Over time, the PIPS conformation accumulates to high levels, leading to ONLINE ANIMATION symptoms of the prion disease.

Nucleus Cytoplasm Neuron -PrpSc -PrpC A prion protein in the PrpSc conformation comes in contact with a PrpC protein, converting it into a PrpSc protein. - Original PrpSc molecule -PrpSc converted from PrpC The 2 PrpSc proteins bind to 2 PrpC proteins, and convert them to PrpSc Over time, all of the PrpC proteins will be converted to PrpSc proteins. FIGURE 25.9 A proposed molecular mechanism of prion diseases. The PrPSc protein catalyzes the conver- sion of a PrP protein to PrP8*. Over time, the PIPS conformation accumulates to high levels, leading to ONLINE ANIMATION symptoms of the prion disease.

Anatomy & Physiology

1st Edition

ISBN:9781938168130

Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Chapter3: The Cellular Level Of Organization

Section: Chapter Questions

Problem 6RQ: Because they are embedded within the membrane, ion channels are examples of ________. receptor...

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