OH Ph Ph NH2 TFA (+)-13 (10 mole%). NaBH4, CICO,CHз Меон, -50 to 0 "C CH;CN-H20 0 °C, 24 h quant. yield Pyridine OCH3 [12] OCH3 H3CO H3CO MgBr 16 THF, -30 °C to rt 2 h, 36% (3 steps) HO, OCH3 17 [14] NaBHд, EtOH 0 °C to rt, 1 h 43% (3 steps) endo only Li, liq NH3 THF, -78 °C 15 min, 68% H3CO H3CO ÓCH3 ÓCH3 OCH3 Expected product 10 HO 18 Observed product 15
OH Ph Ph NH2 TFA (+)-13 (10 mole%). NaBH4, CICO,CHз Меон, -50 to 0 "C CH;CN-H20 0 °C, 24 h quant. yield Pyridine OCH3 [12] OCH3 H3CO H3CO MgBr 16 THF, -30 °C to rt 2 h, 36% (3 steps) HO, OCH3 17 [14] NaBHд, EtOH 0 °C to rt, 1 h 43% (3 steps) endo only Li, liq NH3 THF, -78 °C 15 min, 68% H3CO H3CO ÓCH3 ÓCH3 OCH3 Expected product 10 HO 18 Observed product 15
Chapter7: Statistical Data Treatment And Evaluation
Section: Chapter Questions
Problem 7.9QAP
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