One of the regulators of the TCA cycle is succinyl CoA. Discuss the rationale for this molecule to be used to regulate the TCA cycle. So then why is this molecule a reasonable choice as an inhibitor of the TCA?
One of the regulators of the TCA cycle is succinyl CoA. Discuss the rationale for this molecule to be used to regulate the TCA cycle.
- So then why is this molecule a reasonable choice as an inhibitor of the TCA?
The TCA or Tricarboxylic acid cycle, also called as the citric acid cycle, is a series of reactions occurring in the mitochondria of eukaryotic cells (or cytoplasm of prokaryotic cells). The cycle involves oxidation of acetyl-CoA to produce NADH and precursors for various biomolecules. The NADH is used in the oxidative phosphorylation reaction to produce usable energy in the form of ATP.
Succinyl-CoA is one of the intermediates produced in the TCA cycle and is a thioester compound of succinic acid and coenzyme A (CoA). It is synthesized from α-ketoglutarate by the enzyme α-ketoglutarate dehydrogenase using a decarboxylation reaction involving removal of CO2 and addition of a CoA molecule.
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