One of the ways in which an L a-amino acid can be synthesized is to carry out an Sy2 reaction between an a-bromo acid and ammonia. (The wavy line indicates that the bond could be a dash or a wedge.) Draw the stereoisomer of the a-bromo acid that would be necessary Br. H3N. R An a-bromo acid An L a-amino acid to produce L-alanine, in which the R group is CH3.
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- Why an amino group (NH2) directs electrophilic aromatic substitutionto the ortho and para positions ?According to the paper, F486 is a phenylalanine residue (i.e., an amino acid that is part of a chain that forms a protein) on SARS-CoV-2. It has an important interaction with ACE2 (best seen in Fig. 1(C) and Fig. 2(A)). Looking at this phenylalanine and the green residues surrounding it, which statement best describes the interaction that could be occurring? a) It forms a hydrogen bond with Y83. b) It forms a dipole-dipole interaction with M82. c) It forms London dispersion forces with surrounding residues. d) It encounters repulsions from surrounding residues.Triethylenemelamine (TEM) is an antitumor agent. Its activity is due to its ability to cross-link DNA. a. Explain why it can be used only under slightly acidic conditions. b. Explain why it can cross-link DNA.
- Triethylenemelamine (TEM) is an antitumor agent. Its activity is due to its ability to cross-link DNA. a. Explain why it can be used only under slightly acidic conditions.b. Explain why it can cross-link DNA.Write out the steps needed to synthesize the following peptide using the Merrifield method.The reaction of ninhydrin with an -amino acid occurs in several steps (a) The first step is loss of water to give a triketone. Show the mechanism of the reaction and the structure of the triketone.(b) The second step is formation of an imine by reaction of the amino acid with the triketone. Show its structure. (c) The third step is a decarboxylation. Show the structure of the product and the mechanism of the decarboxylation reaction. (d) The fourth step is hydrolysis of an imine to yield an amine and an aldehyde. Show the structures of both products. (e) The final step is formation of the purple anion. Show the mechanism of the reaction
- Give typed solution only Which of the amino acids shown represents the structure of Ile at pH 10?By using only amide/Peptide bond forming rxn and a lKylation rxns. Provide all the reaction steps with the reagent needed and conditions with out showing the mechanism for each step to form the product. Note: Use protecting groups like (Boc, Fmoc, and others) H2NNH2+Protein: SHAYNERSE Predict the products of the following reactions with the protein given, if there is none, write NO RXN. - Biuret reagent - KOH/Pb(CH2COO)2 - Glyoxilic Acid/Conc. H2SO - Hg/HNO3 - HNO3
- For an Electrophilic Aromatic substitution of Nitrobenzene and Aminobenzene predict the directing influences of the Nitro and Amino groups respectively on the incoming group. A. Nitro is strongly deactivating and meta directing ; Amino is strongly activating and ortho,para directing. B. Nitro is strongly deactivating and ortho,para directing; Amino is strongly deactivating and ortho, para directing. C. Nitro is strongly deactivating and para directing; Amino is strongly deactivating and ortho directing. D. Nitro is strongly deactivating and ortho,para directing; Amino is strongly activating and meta directing. E. Amino is strongly deactivating and ortho,para directing; Nitro is strongly activating and meta directing. F. Amino is strongly deactivating and meta directing ; Nitro is strongly activating and ortho,para directing.After treatment with peroxyformic acid, the peptide hormone vasopressin is partiallyhydrolyzed. The following fragments are recovered. Propose a structure for vasopressin.Phe@Gln@Asn Pro@Arg@Gly # NH2 Cys@Tyr@PheAsn@Cys@Pro@Arg Tyr@Phe@Gln@AsnIf anisole is allowed to sit in D2O that contains a small amount of D2SO4, what products are formed?