One step in glycolysis is the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. The direct reaction of fructose-6-phosphate with inorganic phosphate fructose-6-phosphate + Pi ⇌ fructose-1,6-bisphosphate + H₂O is very unfavorable, with ∆G'°= 16.3 kJ/mol and K'eq = 1.39×10⁻³. However, in glycolysis the reaction is coupled to ATP hydrolysis: fructose-6-phosphate + ATP ⇌ fructose-1,6-phosphate + ADP and the reaction if favorable. What is the equilibrium [fructose-1,6-bisphosphate]/[fructose-6-phosphate] ratio in the coupled reaction when [ATP] = [ADP]? For ATP hydrolysis ∆G'°= -30.5 kJ/mol at 25°C.

One step in glycolysis is the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. The direct reaction of fructose-6-phosphate with inorganic phosphate fructose-6-phosphate + Pi ⇌ fructose-1,6-bisphosphate + H₂O is very unfavorable, with ∆G'°= 16.3 kJ/mol and K'eq = 1.39×10⁻³. However, in glycolysis the reaction is coupled to ATP hydrolysis: fructose-6-phosphate + ATP ⇌ fructose-1,6-phosphate + ADP and the reaction if favorable. What is the equilibrium [fructose-1,6-bisphosphate]/[fructose-6-phosphate] ratio in the coupled reaction when [ATP] = [ADP]? For ATP hydrolysis ∆G'°= -30.5 kJ/mol at 25°C.

Chemistry: The Molecular Science

5th Edition

ISBN:9781285199047

Author:John W. Moore, Conrad L. Stanitski

Publisher:John W. Moore, Conrad L. Stanitski

Chapter16: Thermodynamics: Directionality Of Chemical Reactions

Section: Chapter Questions

Problem 83QRT: Another step in the metabolism of glucose, which occurs after the formation of glucose6-phosphate,...

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