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Curren'S Math For Meds: Dosages & Sol

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter10: Reconstitution Of Powdered Drugs

Section: Chapter Questions

Problem 7.2P

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Owing to their structural similarity, separation of mixtures of organic compounds (such as the isomers 1-t-
butyl-, 3-t-butyl-, and 4-t-butylcyclohexene) often proves difficult. Silica gel chromatography, however,
can be used with some success provided that sufficient silica gel is used to provide optimal separation.
Consider, for example, the TLC plate pictured at right after developing and UV visualization where prior to
elution, lanes A and B were spotted with 1-t-butylcyclohexene and lanes B and C spotted with 4-t-
butylcyclohexene. Which of the following must be true? In the space provided, indicate the CORRECT
answers (as 1, 2, and/or 3) then explain your reasoning for all three statements.
1. 1-t-butylcyclohexene elutes faster than 4-t-butylcyclohexene.
2. The R; for both 1-t-butylcyclohexene and 4-t-butylcyclohexene are equal.
3. 4-t-butylcyclohexene is less polar than 1-t-butylcyclohexene

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