Phenols (pKa ≈ 10) are more acidic than other alcohols, so they are easily deprotonated bysodium hydroxide or potassium hydroxide. The anions of phenols (phenoxide ions) can beused in the Williamson ether synthesis, especially with very reactive alkylating reagents suchas dimethyl sulfate. Using phenol, dimethyl sulfate, and other necessary reagents, show howyou would synthesize methyl phenyl ether.
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
Phenols (pKa ≈ 10) are more acidic than other alcohols, so they are easily deprotonated by
sodium hydroxide or potassium hydroxide. The anions of phenols (phenoxide ions) can be
used in the
as dimethyl sulfate. Using phenol, dimethyl sulfate, and other necessary reagents, show how
you would synthesize methyl phenyl ether.
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