Please calculate and plot the charge on a peptide with the sequence of NEYK over the pH range from 1 to 13. Please use the pKa values from the table. You may calculate the charge at 1 pH unit intervals.
Please calculate and plot the charge on a peptide with the sequence of NEYK over the pH range from 1 to 13. Please use the pKa values from the table. You may calculate the charge at 1 pH unit intervals.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
Please calculate and plot the charge on a peptide with the sequence of NEYK over the pH range from 1 to 13. Please use the pKa values from the table. You may calculate the charge at 1 pH unit intervals.
Transcribed Image Text:Amino acid
Nonpolar, aliphatic R groups
Glycine
Alanine
Proline
Valine
Leucine
Isoleucine
Methionine
Aromatic R groups
Phenylalanine
Tyrosine
Tryptophan
Polar, uncharged R groups
Serine
Threonine
Cysteine
Asparagine
Glutamine
Histidine
Abbreviation/symbol
Arginine
Aspartate
Gly G
Glutamate
Ala A
Pro P
Val V
Leu L
Ile I
Met M
Phe F
Tyr Y
Trp W
Ser S
Thr T
Positively charged R groups
Lysine
Cys C
Asn N
Gln Q
Lys K
His H
Negatively charged R groups
Arg R
Asp D
Glu E
Mr
a
75
89
115
117
131
131
149
165
181
204
105
119
121
132
146
146
155
174
133
147
pK₁ (-COOH)
2.34
2.34
1.99
2.32
2.36
2.36
2.28
1.83
2.20
2.38
2.21
2.11
1.96
2.02
2.17
2.18
1.82
2.17
1.88
2.19
pką values
pKz(—NH)
9.60
9.69
10.96
9.62
9.60
9.68
9.21
9.13
9.11
9.39
9.15
9.62
10.28
8.80
9.13
8.95
9.17
9.04
9.60
9.67
PKR (R group)
10.07
8.18
10.53
6.00
12.48
3.65
4.25
pl
5.97
6.01
6.48
5.97
5.98
6.02
5.74
5.48
5.66
5.89
5.68
5.87
5.07
5.41
5.65
9.74
7.59
10.76
2.77
3.22
Hydropathy
indexb
-0.4
1.8
-1.6d
4.2
3.8
4.5
1.9
2.8
-1.3
-0.9
-0.8
-0.7
2.5
-3.5
-3.5
-3.9
-3.2
-4.5
-3.5
-3.5
7.2
7.8
5.2
6.6
9.1
5.3
2.3
3.9
3.2
1.4
6.8
5.9
1.9
4.3
4.2
5.9
C
F
2.3
5.1
5.3
6.3
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