Answered: post-doc position at Johns Hopkins…

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section: Chapter Questions

Problem 13QP: The search for the BRCA1 breast cancer gene discussed in this chapter was widely publicized in the...

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Dr. Serena Velazquez lands a coveted post-doc position at Johns Hopkins following completion of her MD/PhD in cancer therapeutics to treat late-stage pancreatic cancer using a mouse model. Her post-doc will be devoted to targeted mutagenesis of replicative enzymes to halt cell division in cancerous cells. She reviews mitosis and meiosis before reporting for her first day of work.

In terms of the eukaryotic replisome, what enzyme would be the first choice for Dr. Velazquez to consider mutating in order to halt DNA replication since it precedes all the others?

a) DNA pol III.

b) Helicase.

c) Topoisomerase.

d) Primase.

If Dr. Velazquez was asked to review an article on the possibility of targeted mutagenesis of the gene for DNA pol III in a human fetus to make it immune to cancer, what do you think her response would be?

a) LMAO! No human would survive without pol III since we need it to help resolve the issue with Okazaki fragments!

b) LOL! Humans aren’t bacteria so WT* are the researchers even thinking?!

c) LMAO! DNA pol I is the main replicative DNA polymerase.

d) Hmmm! Why didn’t I think of that?!!

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