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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 12, Problem 13QP
Textbook Problem
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The search for the BRCA1 breast cancer gene discussed in this chapter was widely publicized in the media (for example, Newsweek, December 6, 1993). Describe the steps taken by Mary-Claire King and her colleagues to clone this gene. How long did this process take?

Summary Introduction

To determine: The steps taken by Mary-claire King and her collegues to clone BRCA1 gene.

Introduction: Breast cancer is the most common form of cancer. Mutation in two different genes BRCA1 and BRCA2 are considered as the major cause for breast cancer. BRCA1 gene is present on the 17th chromosome..  BRCA2 gene is present on the 13th chromosome and mutation in this gene also increases the chances of breast cancer.

Explanation of Solution

The steps followed by Mary-claire King and her collegues to clone BRCA1 gene are as follows:

  • • Mary-claire King mapped the breast cancer gene using linkage disequilibrium analysis. In this process the polymorphisms were identidfied and isolated from the population.
  • • Mary-claire King and her collegues collected DNA samples from genetic relatives of the cancer patients such as siblings, parents, and children, and reconstructed genome maps...
Summary Introduction

To determine: The time taken for the experiment conducted by Mary-claire King and her collegues.

Introduction:

Breast cancer is the most common form of cancer. Mutation in two different genes BRCA1 and BRCA2 are considered as the major cause for breast cancer. BRCA1 gene is present on the 17th chromosome..  BRCA2 gene is present on the 13th chromosome and mutation in this gene also increases the chances of breast cancer.

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