Problem 4: Show the mechanism of the following nucleophilic acyl substitution reaction using curved arrows to indicate the electron flow in each step. H,CO H3CO. NaOH H2O H,CO H;CO Morpholine ÓCH, OCH3 Trimetozine (an amide) 3,4,5-Trimethoxy-benzoyl chloride

Problem 4: Show the mechanism of the following nucleophilic acyl substitution reaction using curved arrows to indicate the electron flow in each step. H,CO H3CO. NaOH H2O H,CO H;CO Morpholine ÓCH, OCH3 Trimetozine (an amide) 3,4,5-Trimethoxy-benzoyl chloride

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter11: Reactions Of Alkyl Halides: Nucleophilic Substitutions And Eliminations

Section11.SE: Something Extra

Problem 37MP

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Concept explainers

Aromatic Compounds

Aromatic organic compound or aromatic system is an important class of hydrocarbons under the branch of organic chemistry. Aromatic compounds are also called arenas. The definition of aromatic organic compounds can be stated as a class of organic compounds with a planar cyclic ring of atoms bonded through alternated single and double bonds. Due to these alternating bonds, a peculiar feature termed as ‘resonance’, that is, delocalization of pi electrons or the electrons is shared within the atoms of the ring which are present in the aromatic compounds. The word ‘aromatic’ includes a Greek word ‘aroma’ which means smell, indicating that they were named as such due to the sweet odor they produce. Many well-known flavors such as vanilla, cinnamon, and few scents from flowers are extracted from aromatic compounds. Benzene with chemical formula C6H6 is a very common aromatic compound that contains six atoms of carbon held in the cyclic ring of alternate double bonds. It is also to be noted that not all aromatic compounds contain benzene ring. This can be explained by Huckel’s rule.

Question

Problem 4: Show the mechanism of the following nucleophilic acyl substitution reaction
using curved arrows to indicate the electron flow in each step.
H,CO.
H,CO.
NAOH
H20
H3CO
H;CO
Morpholine
ÓCH3
ÓCH3
Trimetozine (an amide)
3,4,5-Trimethoxy-benzoyl
chloride

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