Prompts Šubmitted Answers protect cells from uncontrolled proliferation Gain of function Choose a match involve Tumor suppressor genes Oncogenes Choose a match are oncogenes. Mutated forms of proto-oncogenes is seen in tumor suppressor genes, leading to cancer. O are; CMYC, KRAS & ErBb2 Examples of oncogenes are; CMYC, KRAS & ErBb2 O is of relevance to inherited cancers Loss of function Choose a match O are; BRCA1, BRCA2 & TP53 Examples of tumor suppressor genes are; BRCA1, BRCA2 & TP53 is seen in tumor suppressor genes, leading to Tumor suppressor genes Choose a match cancer. Inherited cancer Choose a match is seen in oncogenes, leading to cancer. The Knudson's 2-hit hypothesis requires loss of function in both alleles O requires loss of function in both alleles Both inherited and sporadic cancers Choose a match are not involved in inherited forms of cancer

Prompts Šubmitted Answers protect cells from uncontrolled proliferation Gain of function Choose a match involve Tumor suppressor genes Oncogenes Choose a match are oncogenes. Mutated forms of proto-oncogenes is seen in tumor suppressor genes, leading to cancer. O are; CMYC, KRAS & ErBb2 Examples of oncogenes are; CMYC, KRAS & ErBb2 O is of relevance to inherited cancers Loss of function Choose a match O are; BRCA1, BRCA2 & TP53 Examples of tumor suppressor genes are; BRCA1, BRCA2 & TP53 is seen in tumor suppressor genes, leading to Tumor suppressor genes Choose a match cancer. Inherited cancer Choose a match is seen in oncogenes, leading to cancer. The Knudson's 2-hit hypothesis requires loss of function in both alleles O requires loss of function in both alleles Both inherited and sporadic cancers Choose a match are not involved in inherited forms of cancer

Biology (MindTap Course List)

11th Edition

ISBN:9781337392938

Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Chapter17: Developmental Genetics

Section: Chapter Questions

Problem 8TYU: Which of the following statements about cancer is false? (a) oncogenes arise from mutations in...

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Similar questions

Describe the genetic changes that convert proto-oncogenesinto oncogenes or inactivate tumor-suppressor genes.
A research study indicated that an agent in cigarette smokecaused the silencing of a tumor-suppressor gene called p53.However, using sequencing, no mutation was found in the DNAsequence for this gene. Give two possible explanations for theseresults.
With regard to cancer cells, which of the following statementsare true?A. Cancer cells are clonal, which means they are derived from asingle mutant cell.B. To become cancerous, cells usually accumulate multiplegenetic changes that eventually result in uncontrolledgrowth.C. Most cancers are caused by oncogenic viruses.D. Cancer cells have lost the ability to properly regulate celldivision.
Some germ-line mutations predispose individuals tocancer, yet often environmental factors (chemicals,exposure to radiation) are considered major risks fordeveloping cancer. Do these views of the cause ofcancer conflict, or can they be reconciled?
The normal function of one tumor-suppressor gene acting at the G1 checkpoint is to prevent cells with damaged chromosomes and DNA from “progressing from G1 to S.” Another tumor-suppressor gene, acting at the G2/M checkpoint, prevents “passage from G2 to M.” When these tumor-suppressor genes fail to work, cancer can result. Explain what the phrases in quotations mean.
Which one of the following events is unlikely to beassociated with cancer?a. mutation of a cellular proto-oncogene in a normaldiploid cellb. a chromosomal translocation with a breakpointnear a cellular proto-oncogenec. deletion of a cellular proto-oncogened. mitotic nondisjunction in a cell carrying a deletionof a tumor-suppressor genee. incorporation of a cellular oncogene into a retroviruschromosome
Explain why mutations in tumor suppressor genes are recessive (both copies of the gene must be defective for the regulation of cell division to be defective), whereas mutations in oncogenes are dominant.
''Cancer therapies directed solely at killing the rap-idly dividing cells that make up the bulk of a tumor areunlikely to eliminate the cancer from many patients.'' Is this statement true? Explain why or why not.
Describe three common ways that tumor-suppressor genes aresilenced.
Apart from p53, mention and describe the function of three tumor suppressor genes you know
Shown here are two HeLa cancer cells that are just completing cytokinesis. Explain how the cell division of cancer cellslike these is misregulated. Identify genetic and other changesthat might have caused these cells to escape normal cell cycleregulation
Retinoblastoma is a rare cancer in which tumors developin the retina of the eye. The tumors arise because of theloss of the Rb gene, which codes for a tumor suppressor.Hereditary retinoblastoma usually appears in children whohave inherited only one functional copy of Rb. Explain whythe nonhereditary form of retinoblastoma usually occurs laterin life.