A research study indicated that an agent in cigarette smokecaused the silencing of a tumor-suppressor gene called p53.However, using sequencing, no mutation was found in the DNAsequence for this gene. Give two possible explanations for theseresults.

Q: ''The cell cycle is the ticking clock that sets thetempo of developmental processes, with…

A: Cell cycle is the alternate growth and division phase of cells. Cell cycle is crucial process during…

Q: Oncogenes show a of mutation, while tumor suppressor genes show a of mutations. is the process by…

A: Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread…

Q: The p53 gene was discovered in 1979, but it was not clear whether the gene functioned as an oncogene…

A: An oncogene is a type of gene that is responsible for causing the cells to divide uncontrollably and…

Q: Analyze the feedback loop between cell proliferationand genomic instability in cancer cells.

A: Feedback loop is defined as a system’s part in which the output of a system are routed back as input…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Induced pluripotent stem cells (iPS) is a type of stem cell(pluripotent) in nature that is derived…

Q: Occurred in her cells? (Unfortunately her parents have passed away.) I think these genes are…

A: CRISPR stands for Clustered regularly interspaced short palindromic repeats. It is a system of…

Q: Mutations in three broad classes of genes have been implicated in the onset of cancer. Can you…

A: A Mutation occurs when a DNA gene is damaged or changed in such a way as to alter the genetic…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Medical technology has advanced significantly over the course of many centuries. According to…

Q: Describe three common ways that tumor-suppressor genes aresilenced.

A: Tumour suppressor genes are genes that can decrease the rate of cell division and growth. In the…

Q: why EGFR play a role in CRC and other cancer?

A: EGFR : It is epidermis growth factor receptor.  CRC:  Colorectal cancer. EGFR : It is one of the…

Q: If cancer is fundamentally a genetic disease, how might an environmental factor such as smoking…

A: Tumor is a mass of tissues. It may be benign or malignant. The cellular growth that occurs when the…

Q: Which of the following mutations is MOST likely to cause cancer? A) a mutation that causes a cyclin…

A: Introduction- Cancer is a caused by the disturbances in the  controls which regulate cells and this…

Q: Which Is not one of the ways that a proto-oncogene can become converted into an oncogene? O…

A: A proto oncogene is a type of gene which is responsible for suppression of tumor example is p53  Its…

Q: Cancer causing genes are called ________. a. transformation genes b. tumor suppressor genes c.…

A: Cancer is a fast growing chronic disorder nowadays. It is caused due to lack of or absence of…

Q: A carcinogenic compound is placed on the skin of inbred laboratory mice. In many of these mice, skin…

A: A carcinogenic substance is any substance or particle that induces the cancer formation in the host…

Q: Although tobacco smoking is responsible for a large number of human cancers, not all smokers develop…

A: Cancer refers to the uncontrolled cell division caused by the mutations in the genes which control…

Q: Mammography is an accurate screening technique for the earlydetection of breast cancer in humans.…

A: Cancer is a devastating medical condition characterized by the growth of abnormal cells in the body…

Q: Describe the roles of proto-oncogenes and tumor suppressor genes in controlling cell growth, and…

A: Oncogenesis is the process of inducing cancer in the body due to mutation in the genes. Oncogenes…

Q: Which of the following is involved in the formation of cancer? O mutations in genes involved in DNA…

A: Cancer is a disease in which cells of the body multiply uncontrollably and form tumours.  Cancer is…

Q: Some germ-line mutations predispose individuals tocancer, yet often environmental factors…

A: A germline mutation is also called a germinal mutation. It refers to identifiable changes in the…

Q: A research study indicated that an agent in cigarette smoke caused the silencing of a tumor…

A: The TP53 gene provides instructions for making a protein called tumor protein p53 (p53). This…

Q: Normal (nonmutant) tumor-suppressor genes often functiona. as negative regulators of cell…

A: Cancer is defined as the biological disorder in which the cells undergo uncontrolled growth and cell…

Q: . Explain why mutations in oncogenes are generally dominant while those in tumor suppressor genes…

A: Proto-oncogenes and tumour suppressor genes are two types of gene essential for the control of cell…

Q: Unlike many other diseases, the vast majority of cancers in humans are not transmissible - meaning a…

A: Cancer is "referred" to as any abnormal growth of cell tissue. Cancer can develop anywhere in the…

Q: In other words, the master regulator initiates a program of gene expression that narrow the…

A: Cell signalling

Q: Many of the mutations in cancer samples are not necessarily driver mutations, but rather passenger…

A: Hematologic childhood cancer can develop in any part of the body, including the blood and lymph…

Q: Which of the following statements about cancer is false? (a) oncogenes arise from mutations in…

A: Proto Oncogenes are the genes that cause cancer when there are alterations in them. Several factors…

Q: Which one of the following events is unlikely to beassociated with cancer?a. mutation of a cellular…

A: Cancer is basically the uncontrolled proliferation of abnormal or mutated cells in the body. It is…

Q: Distinguish between proto-oncogene and oncogene. Describe two mechanisms by which genetic change…

A: Oncogene refers to the cancer-causing gene and is expressed in higher concentration in tumor cells…

Q: Lord Voldemort seeks immortality to rule over the wizarding and muggle world forever. As his loyal…

A: Cancer is a condition in which the cells undergoes continuous cycle without stopping and doesn’t…

Q: Of the following choices a loss of function mutation would most lukely contribute to cancer onset if…

A: Normal DNA contains a particular sequence of DNA. If the sequence of DNA is changed due to external…

Q: ____________ is the most common tumor suppressor gene that is often mutated in human cancers.

A: Tumor suppressor gene are also known as the anti oncogenes which performs the function of regulation…

Q: mutation in p53 promoter that prevents p53 from being expresses Causes? Why? A. Increased…

A: Cancer is a condition in the body where cells in particular tissues lose the function of apoptosis…

Q: How tumor-suppressor mutations contribute to cancer?

A: Cancer - Cancer is a type of disease in which cells divide in an uncontrolled manner. The cells…

Q: When the DNA of a human cell becomes damaged, the p53 geneis activated. What is the general function…

A: p53 gene: Tumor protein p53 gene also  p53 is a protein encoded by homologous genes in various…

Q: How does the normal p53 protein inhibit cancer development?

A: Tumor-suppressor genes code for proteins that repair damaged DNA (preventing a cell from turning…

Q: Which of the following statements correctly describes a characteristic of tumor-suppressor gene? a)…

A: Cells that progress through the cell cycle unchecked may sequentially develop malignant tumors.…

Q: Retinoblastoma is a rare cancer in which tumors developin the retina of the eye. The tumors arise…

A: The genes are the primary unit of life. The nucleotide sequence of the genes are responsible for…

Q: Geneticists have found a number of different gene mutations that have led to the development of…

A: Mitosis is the type of cell division in which one cell divides to reproduce two identical cells.…

Q: Can this trait be passed to offspring?

A: Mutations are the random changes in the genome of an organism. Mutations in the genome of somatic…

Q: Although cancer is not a contagious disease in humans or other vertebrates, there have been rare…

A: Cancer cannot be infected from oone person to another. It cannot spread through direct contact like…

Q: Why does a single mutation in a proto-oncogene, turning it into an oncogene potentially lead to a…

A: Proto- oncogene Activation of a proto- oncogene into an oncogene usually includes gain of function…

Q: One major goal of modern cancer therapy is toidentify small molecules—anticancer drugs—that canbe…

A: Anticancer drugs are used against cancer. Chemotherapy drugs kill cancer cells by stopping them from…

Q: With regard to cancer cells, which of the following statementsare true?A. Cancer cells are clonal,…

A: Cancer is a group of diseases involving abnormal growth of cells, which tend to proliferate in an…

Q: Some cancers have been treated with drugs that demethylate DNA.Explain how these drugs might work.…

A: Cancer is a disease that is associated with genetic changes. The mutations in the oncogenes and…

Q: Discuss the relationship between cancer and changes in gene expression that affect cell…

A: Cancer is the condition in which the control over the process of cell division is lost.

Q: Imagine you have used cBioportal and breast cancer patient datasets and identified a…

A: Introduction :- Cancer is defined as the uncontrolled and un-regulated proliferation of cells , due…

Q: Which of the following is 'a characteristic of malignant tumors, but not benign tumors? a) Mutation…

A: Abnormal growth of the cells results in tumors. When the cells in the tumor are normal, it is…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.