Protein SUMOylation can have a large variety of functions (whereas the proteossome goes to degradation, SUMOylation has many more characteristics). a) Identify 3 of these functions. b) Explain how can the same modification have such diverse functions?

Anatomy & Physiology
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ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
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Protein SUMOylation can have a large variety of functions (whereas the proteossome goes to degradation, SUMOylation has many more characteristics).

a) Identify 3 of these functions.

b) Explain how can the same modification have such diverse functions?

Signaling functions of SUMO
yclex
CycLex Co., Ltd. All Rights Reserved.
Higher-order
chromatin structure
Differential
Antagonism
of ubiquitination
protein-protein
interaction
Sumo
Nuclear pore
complex shuttling
Substrate
Subcellular
localization
Integrity of PML
nuclear bodies
Transcription
factor activity
Regulation
of DNA binding
Transcribed Image Text:Signaling functions of SUMO yclex CycLex Co., Ltd. All Rights Reserved. Higher-order chromatin structure Differential Antagonism of ubiquitination protein-protein interaction Sumo Nuclear pore complex shuttling Substrate Subcellular localization Integrity of PML nuclear bodies Transcription factor activity Regulation of DNA binding
SUMO E1, E2, E3 enzymes, ATP
SUMO
Target
Target
Isopeptidases
b
Partner A
SUMO
SUMO
Target
Target
Target
Partner B
Transcribed Image Text:SUMO E1, E2, E3 enzymes, ATP SUMO Target Target Isopeptidases b Partner A SUMO SUMO Target Target Target Partner B
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