Glycosphingolipids function via cis regulation and trans recognition. Explain these terms and provide examples of each.
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1. Glycosphingolipids function via cis regulation and trans recognition. Explain these terms and provide examples of each.
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- Briefly describe each of the following possible posttranslational protein modifications. Give an example of each. Cross-linkage glycosylation and phosphorylation cleavage assembly into polymeric proteins (> 1 polypeptide)1. What are congenital disorders of glycosylation (CDGs)?1 What is the dominant biochemical activity or molecular interaction that your protein is predicted to carry out? Which sites on the protein contribute to the process directly? Which sites contribute indirectly? protein = amyloid-beta precursor
- 2 Please draw the arrow-pushing mechanism to create the polyketide backbone chain of TYLOSIN. If two or more extension rounds are exactly the same, you do not need to draw them more than once. However, please clearly indicate which steps are being repeated. Please draw the complete “business end” of any cofactors you use in a step1. Explain the formation of thioether-linked prenyl anchor proteins and also explain the structure of caveolae.2. A group of peptides that influence nerve transmission in certain parts of the brain have been isolated from normal brain tissue. These peptides are known as opioids. Using the information below, determine the amino acid sequence of this particular opioid: ● Complete hydrolysis by HCl at 100° C followed by amino acid hydrolysis analysis indicated the presence of Gly, Leu, Phe, and Tyr, in a 2:1:1:1 ratio. ● Treatment of the peptide with FNDB followed by complete hydrolysis indicated the presence of 2,2-dinitrophenyl derivative of tyrosine. No free tyrosine could be found. ● Complete digestion of the peptide with chymotrypsin yielded free tyrosine and leucine, plus a tripeptide containing Phe and Gly in a 1:2 ratio. Instructions Make use of the table below to determine the sequence of the mystery protein:
- 7. Which of the following events does NOT take place in/on the RER? a. cleavage of the signal recognition peptide b. biosynthesis of core oligosaccharides for N-linked glycosylation c. Phosphorylation of mannose to give rise to mannose-6-phosphate. d. attachment of a core oligosaccharide to protein via asparagine residues e. cleavage of GTP by SRP receptorplease indicate at the structural level how 3TCworks as a deoxycytosine analog, and why it is a chainterminator!!!Show the steps involved in a Merrifield synthesis of Phe-Ala-Val.
- Define multiubiquitinylation.Explain the role that Gla residues play in complexes. Explain the role of vitamin K / warfarins in the synthesis of protease factors and list the Vitamin K-dependent factorsWhat peptides are expected to be produced when α-melanotropin is cleaved by (a) trypsin, (b) cyanogen bromide, or (c) thermolysin? (as shown)