QUESTION 44 In adult neurons, there is a higher concentration of chloride outside the cell than inside the cell. During development, intracellular chloride concentrations are much higher such that GABA causes excitation of the postsynaptic neuron. Why could changing the CI¯ concentration result in excitation? Higher concentrations of CI¯ prevent the release of GABA from the presynaptic neuron. There is a smaller Ca2* conductance. ECi is now more positive than the action potential threshold. ECi is now more negative than the action potential threshold.
QUESTION 44 In adult neurons, there is a higher concentration of chloride outside the cell than inside the cell. During development, intracellular chloride concentrations are much higher such that GABA causes excitation of the postsynaptic neuron. Why could changing the CI¯ concentration result in excitation? Higher concentrations of CI¯ prevent the release of GABA from the presynaptic neuron. There is a smaller Ca2* conductance. ECi is now more positive than the action potential threshold. ECi is now more negative than the action potential threshold.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:QUESTION 44
In adult neurons, there is a higher concentration of chloride outside the cell than inside the cell. During development, intracellular chloride
concentrations are much higher such that GABA causes excitation of the postsynaptic neuron. Why could changing the CI¯ concentration
result in excitation?
Higher concentrations of CI¯ prevent the release of GABA from the presynaptic neuron.
There is a smaller Ca2* conductance.
ECi is now more positive than the action potential threshold.
ECI is now more negative than the action potential threshold.
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