Ran and Rab are both involved in transport of proteins in the cell. Match the function with the correct protein. Involved in nuclear import/export A. Ran GEF When bound to GTP, binds import receptor, and B. Ran GAP releases cargo into nucleus C. Rab • Plays a role in targeting vesicles to correct membrane D. Ran When GTP is hydrolyzed releases vesicle and effector
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- Opiods cause ligand-gated K+ channels to open and move with their concentration gradient from high to low (into or out) Blank 1. Fill in the blank. of the cell, causing the membrane potential to (hyperpolarize or depolarize) Blank 2. Fill in the blank. Fill in the blank using one of the options in the parenthesisWhich of the following elements may be in the transduction part of cell signaling? Select one: a. A phosphatase b. A kinase c. cyclin AMP d. ions e. All answers are correctDuring repolarization of the plasma membrane,a. Na+ diffuses into the cell.b. Na+ diffuses out of the cell.c. K+ diffuses into the cell.d. K+ diffuses out of the cell.
- Which part of the AK rules with the effector cell ? Select one .A. Fc regionB .Sugar chainsc. Hinge region. d. Fab regionWhich of the following are true of nuclear trafficking? Select one or more: a. RAN-GTP (when bound to GTP) LEAVES the nucleus. b. includes importins which help move proteins into the nucleus and exportins that move proteins out of the nucleus. c. Ran-GDP (When bound to GDP) enters the nucleus d. the NLS is cleaved upon import to the nucleusAn enzyme-linked receptor (a) is a cytoplasmic protein (b) would not be found on plant cell surfaces (c) forms a dimer with another enzyme-linked receptor when a ligand binds to it (d) is typically an adenylyl cyclase molecule(e) typically activates ion channels
- The inner nuclear membrane contains a) None of these choices are accurate b) proteins including chaperonins and translocon c) integral membrane proteins including emerin, the lamin B receptor (LBR), and the SUN proteins d) peripheral membrane proteins including KASH and SUNWhich statement is not true of endoplasmic reticulum? There is smooth and rough endoplasmic reticulum It is found in all living cells. Rough ER has ribosomoes bound to it. Proteins are transported and modified within it Proteins cam be targeted for ER transportationIf a membrane protein is described as "integral" what does that word refer to? A) super important; plays a key function B) It is bonded to a non protein molecule like a sugar chain or lipid C) It must be an ID tage/ cell recognition protein D) It is strongly integrated/ embedded into the membrane likely spanning the entire width
- Which of the following is associated with a decrease in cell-cell interactions? Select one: a. loss of MMPs b. loss of basement membrane proteins c. increased integrin expression d. Loss of integrins e. loss of E-cadherinWhat would happen to nuclear transport if you removed all of the Ran-GAP? For a while nuclear import receptors will still deliver cargo to the inside of the nucleus Nuclear import receptors will be loaded with RanGTP and will gradually stop binding to the proteins with NLS signals Nuclear export receptors will no longer deliver their cargo to the outside of the membrane and will probably shuttle in and out of the nucleus full of cargo Ran-GDP will no longer be made All of the aboveWhich is not true during the dissolution of nuclear membrane A) lamins dissociate into free lamin dimers B)fragmentation of membrane to vesicles C) inactivation of Cdc2 kinase protein resulting to chromosome condensation D)nuclear pore complex dissociates