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Hemophilia and color blindness are both recessive conditions caused by genes on the X chromosome. To calculate the recombination frequency between the two genes, you draw a large number of pedigrees that include grandfathers with both hemophilia and color blindness, their daughters (who presumably have one chromosome with two normal alleles and one chromosome with two mutant alleles), and the daughters’ sons. Analyzing all the pedigrees together shows that 25 grandsons have both color blindness and hemophilia, 24 have neither of the traits, 1 has color blindness only, and 1 has hemophilia only. How many centimorgans (map units) separate the hemophilia locus from the locus for color blindness?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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Section
BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 15, Problem 2QP
Textbook Problem
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Hemophilia and color blindness are both recessive conditions caused by genes on the X chromosome. To calculate the recombination frequency between the two genes, you draw a large number of pedigrees that include grandfathers with both hemophilia and color blindness, their daughters (who presumably have one chromosome with two normal alleles and one chromosome with two mutant alleles), and the daughters’ sons. Analyzing all the pedigrees together shows that 25 grandsons have both color blindness and hemophilia, 24 have neither of the traits, 1 has color blindness only, and 1 has hemophilia only. How many centimorgans (map units) separate the hemophilia locus from the locus for color blindness?

Summary Introduction

To determine: The distance (in centimorgans) between the hemophilia locus and color blindness locus in a family of 51 members. Out of all, 1 has only color blindness and 1 has only hemophilia.

Introduction: The distance between two genes that are present on the same chromosome can be expressed in a percentage of crossing over. 1 map unit describes 1% of the crossover frequency. The map unit is also called centimorgan or cM.

Explanation of Solution

In a family of 51 members, 25 members have both color blindness and hemophilia, 24 members have neither of the traits, 1 member has only color blindness, and 1 member has hemophilia only. This condition shows that the allele for color blindness and hemophilia underwent crossing over in 2 of the 51 family members...

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