reversibly in this glutamine analog is The group on carbon no. 6-Diazo-5-oxonorleucine (DON) irreversibly inhibits glutamine-dependent amidotransferases. irreversibly and is thought to alkylate the position in the enzyme that becomes amidated by glutamine HC=NEN amidotransferase reactions. This access to the site by glutami 2 c=0 carbonyl 1. 3 H2C H,N-CH diazomethyl coo non-reactive provides carboxyl blocks reactive amino

Pushing Electrons
4th Edition
ISBN:9781133951889
Author:Weeks, Daniel P.
Publisher:Weeks, Daniel P.
Chapter5: Some Reactions From Biochemistry
Section: Chapter Questions
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reversibly
in this glutamine analog is
The
group on carbon no
6-Diazo-5-oxonorleucine (DON) irreversibly
inhibits glutamine-dependent amidotransferases.
irreversibly
and is thought to alkylate the position in the enzyme that becomes amidated by glutamine
amidotransferase reactions. This
access to the site by glutamine.
HC=N N
C=0
carbonyl
H2C
1
H2C
diazomethyl
H2N-CH
4
coo
non-reactive
provides
5
carboxyl
blocks
reactive
amino
Transcribed Image Text:reversibly in this glutamine analog is The group on carbon no 6-Diazo-5-oxonorleucine (DON) irreversibly inhibits glutamine-dependent amidotransferases. irreversibly and is thought to alkylate the position in the enzyme that becomes amidated by glutamine amidotransferase reactions. This access to the site by glutamine. HC=N N C=0 carbonyl H2C 1 H2C diazomethyl H2N-CH 4 coo non-reactive provides 5 carboxyl blocks reactive amino
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