S3) When a patient is diagnosed with breast cancer, the oncologist will typically take a sample of the tumorand test it for the presence of estrogen receptor (ER). If the tumor is ER positive, the patient will usually beprescribed a certain class of drug, and if the tumor is negative, they will be prescribed something different. Themethods of testing for the presence of ER include protein-based methods, such as immunohistochemistry(IHC), and measures of ER mRNA using the quantitative reverse transcriptase polymerase chain reactionassay (PCR). To determine the extent of agreement between these two methods, investigators conducted astudy using banked samples from 1500 breast tumors. Each sample was tested using both methods. Bothmethods provide a positive result for 34 samples, and both methods provide a negative result for 1376samples. The remaining samples were rated differently by the two methods, with IHC generating a total of 75positive findings.a) Fill in the following table using the information provided abovePCR++IHCTotalb) Calculate the overall percent agreementc) Calculate the paired percent agreementTotald) Calculate the kappa statistic and provide a brief interpretation

Since you have asked posted a question with multiple sub-parts, we will solve the first three…

Answered: S3) When a patient is diagnosed with…

MATLAB: An Introduction with Applications

6th Edition

ISBN:9781119256830

Author:Amos Gilat

Publisher:Amos Gilat

Chapter1: Starting With Matlab

Section: Chapter Questions

Problem 1P

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A recent report states that 55% of U.S. adults use Netflix to stream shows and movies. An advertising company believes the proportion of California residents who use Netflix is greater than the national proportion, because Netflix headquarters is located in Los Gatos, California. The company selects a random sample of 600 adults from California and finds that 360 of them use Netflix. Is there convincing evidence at the alpha = .05 level that more than 55% of California residents use Netflix?
True or False
What is the purpose of testing whether ᵝ1=0? If we reject ᵝ1=0, does it imply a good fit?
In the article “Assessment of Dermatopharmacokinetic Approach in the Bioequivalence Determination of Topical Tretinoin Gel Products” (L. Pershing, J. Nelson, et al., Journal of the American Academy of Dermatology, 2003:740-751), measurements of the concentration of an anti-fungal gel, in ng per square centimeter of skin, were made one hour after application for 49 individuals. Following are the results. The authors claim that these data are well-modeled by a lognormal distribution. Construct an appropriate probability plot, and use it to determine whether the data support this claim. 132.44 76.73258.46177.46 73.01130.62235.63 107.54 75.95 70.37 88.76104.00 19.07174.30 82.87 68.73 41.47120.44136.52 82.46 67.04 96.92 93.26 72.92138.15 82.43245.41104.68 82.53122.59147.12129.82 54.83 65.82 75.24 135.52132.21 85.63135.79 65.98349.71 77.84 89.19102.94166.11168.76155.20 44.35202.51 Figure 4.23 (page 288) shows that nonnormal data can sometimes be made approximately normal by applying an…
Can I use CRONBACH’S ALPHA in testing the reliability of the device? How?
A new chemotherapy drug is released to treat leukemia and researchers suspect thst the drug may have fewer side effects than the most commonly used drug to treat leukemia. The two drugs have equivalent efficacy. In order to determine if a larger study should be conducted to look into the prevalence of side effects for the two drugs, set up a Mann-Whitney U test at the alpha equals .05 level and interpret its results. Number of reported side effects Old drug 0 1 3 3 5 New drug 0 0 1 2 4
A selected, inbred rat strain had a tail measuring an average of 5.4 cm. An inbred, wild caught strain had 6.2 cm long tails. The selected and wild caught strains were crossed producing the F1 and F2 below. Generation Progeny Phenotype F1 20 5.8 cm F2 250 5 to 6.6 cm a) Assume that 4 genes control tail length. What is the average contribution per allele in the F2 generation? b) What proportion of the F2 would have tails 6 cm in length? c) Which of the following best describes the PARENTAL rat strains? AAbbCCDD x aaBBccdd AABBCCDD x aabbccdd AABBccdd x aabbCCDD d) How many offspring (approximately) in the F2 would have 5 cm long tails?
Prior to an intensive TV advertising campaign, the producers of Nike athletic shoes find that 29 of a random sample of 200 upper-income adults are aware of their new leisure shoe line. A second random sample of 300 such adults is taken after the campaign. Now 96 of the persons sampled can identify the new line. Is the increase in the proportion of upper income adults showing brand awareness significant? Test the claim using alpha = .05.
A researcher conducts a two-year study comparing the number of cavities in a group of 30 randomly selected young children from the community before and after the application of fluoride to test if there is a decrease in the number of cavities. This is an example of a/an: Independent-samples t test or Dependent-samples t test?
Let yit denote the outcome of a random variable for the i-th individual at time and let Xit denote a covariate measure on the i-th individual at time t, t, i = 1, ..., n, t = 1,..., T. The data could be modeled using the simple linear regression model: Yit = Bo + B₁xt + Eit, Eit~N(0, t) a) Explain why using this approach may be inappropriate. b) Write a mathematical expression of the random intercept model and the random coefficients models as alternatives to this model. c) Provide an expression for the proportion of variance attributable to each of the variance components in the random coefficients models. d) Write out an expression for the likelihood, priors and posterior for the model in part (c) e) Write out a WinBUGS code for this problem.
700 doctors went through extra training compared to 1200 doctors who did not. Of the doctors who went through extra training, 125 of them majored in psychology. Of the 1200 doctors who did not do extra training, 174 of them majored in psychology. Perform a hypothesis test to see if there is a statistically significant evidence that the proportion of doctors who went through extra training is significantly greater than the proportion of doctors who did not. Perform the test at the alpha = .5 level. What is the p value and conclusion of this test?

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