Sickle cell anemia is a disease that is caused by a mutation in the gene that produces hemoglobin. Hemoglobin carries oxygen in red blood cells. The HbA allele produces normal hemoglobin and the HbS allele produces hemoglobin that sticks together and causes red blood cells to sickle. Heterozygous individuals (HbAHbS) produce both normal and "sickle" hemoglobin so the HbA and HbS alleles are codominant. Heterozygotes do not develop sickle cell anemia and are described as having the sickle cell trait. Individuals that are homozygous for the sickle allele (HbSHbS) only produce "sickle" hemoglobin and develop sickle cell disease. A man who is homozygous for the normal allele married a woman with the sickle cell trait. What is the expected probability of this couple having a boy with the sickle cell trait? Record your answer as a value between 0 and 1 rounded to two decimal places.

Sickle cell anemia is a disease that is caused by a mutation in the gene that produces hemoglobin. Hemoglobin carries oxygen in red blood cells. The HbA allele produces normal hemoglobin and the HbS allele produces hemoglobin that sticks together and causes red blood cells to sickle. Heterozygous individuals (HbAHbS) produce both normal and "sickle" hemoglobin so the HbA and HbS alleles are codominant. Heterozygotes do not develop sickle cell anemia and are described as having the sickle cell trait. Individuals that are homozygous for the sickle allele (HbSHbS) only produce "sickle" hemoglobin and develop sickle cell disease. A man who is homozygous for the normal allele married a woman with the sickle cell trait. What is the expected probability of this couple having a boy with the sickle cell trait? Record your answer as a value between 0 and 1 rounded to two decimal places.

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Description: Sickle cell anemia is a disease that is caused by a mutation in the gene that produces hemoglobin. Hemoglobin carries oxygen in red blood cells. The HbA allele produces normal hemoglobin and the HbS allele produces hemoglobin that sticks together a

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter19: Introduction To Genetics

Section: Chapter Questions

Problem 4CT: The young woman shown at right has albinismvery pale skin, white hair, and pale blue eyes. This...

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Sickle cell anemia is a disease that is caused by a mutation in the gene that produces hemoglobin. Hemoglobin carries oxygen in red blood cells. The HbA allele produces normal hemoglobin and the HbS allele produces hemoglobin that sticks together and causes red blood cells to sickle. Heterozygous individuals (HbAHbS) produce both normal and "sickle" hemoglobin so the HbA and HbS alleles are codominant. Heterozygotes do not develop sickle cell anemia and are described as having the sickle cell trait. Individuals that are homozygous for the sickle allele (HbSHbS) only produce "sickle" hemoglobin and develop sickle cell disease. A man with the sickle cell trait married a woman with the sickle cell trait. Determine the probability that they will have children with the sickle cell trait or sickle cell disease.Record your answer as a value between 0 and 1 rounded to two decimal places. Answer
Sickle cell anemia is caused by an individual carrying two recessive copies of the hemoglobin gene (hemoglobin gene is labeled Hb, and the recessive version is Hbs). Thus, to have sickle cell anemia, a person must have the genotype HbSHbS. A person that is HbAHbA carries two copies of the normal hemoglobin gene and does not have sickle cell anemia. A person that is heterozygous (HbAHbS) produces enough normal hemoglobin to not have sickle cell anemia but is also resistant to malaria. People that are heterozygous are called “carriers” because they carry the recessive allele but do not express the recessive phenotype. a. A couple are both resistant to malaria but do not have sickle cell anemia. Draw a Punnett square to represent this cross. b. What is the probability that the couple has three children where one child does not have a recessive allele, one child is resistant to malaria and does not have sickle cell anemia, and one child has sickle cell anemia?
Sickle cell anemia is an inheritable red blood cell disorder that results in sickle-shaped red blood cells. The sickle-shaped red blood cells can stick to blood vessel walls and cause a blockage or slow the movement of blood throughout the body. Individuals who are heterozygous produce both normal and sickle-shaped red blood cells which gives them resistance to malaria but they do not develop sickle cell anemia (so heterozygotes are unaffected on the pedigree).Let HbS be the allele for sickle cell anemia and let HbA be the allele for normal red blood cells. Which of the following rows provides the correct genotypes for individuals I-2, I-4, II-1, and III-1? Select one: a. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbA_ b. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbAHbS c. I-2 I-4 II-1 III-1 HbAHbS HbAHbS HbAHbS HbAHbS d. I-2 I-4 II-1 III-1 HbAHbA HbAHbA HbAHbA HbAHbA
Sickle-cell disease is an autosomal recessive genetic disorder. How many mutated hemoglobin alleles do people with sickle-cell disease have?
Given that the normal hemoglobin allele (H) is dominant to the sickle-cell allele (h), each time two Hh individuals have a child together, what is the chance that the child will have sickle-cell disease? (a) 0% (b) 75% (c) 25% (d) 50% (e) 100%
A human gene called the β-globin gene encodes a polypeptide that functions as a subunit of the protein known as hemoglobin. Hemoglobin carries oxygen within red blood cells. In human populations, the β-globin gene can be found as the more common allele called the HbA allele, but it can also be found as theHbS allele. Individuals who have two copies of the HbS allele have the disease called sickle cell disease. Are the followingexamples a description of genetics at the molecular, cellular, organism, or population level?A. The HbS allele encodes a polypeptide that functions slightly differently from the polypeptide encoded by the HbA allele.B. If an individual has two copies of the HbS allele, that person’s red blood cells take on a sickle shape. C. Individuals who have two copies of the HbA allele do not have sickle cell disease, but they are not resistant to malaria. People who have one HbA allele and one HbS allele do not have sickle cell disease, and they are resistant to malaria.…
Suppose two parents are healthy carriers of the sickle cell allele. The genotype of each parent is HbAHbS (HbAis the normal allele, and HbS is the sickle-cell allele).How likely is it for a child of these parents to have sickle cell anemia (HbSHbS)?
Albinism is a recessive disorder where there is a lack of melanin. Andrea and her husband Claude both have normal skin pigmentation. Andrea’s mother has the albino phenotype, but her father and her brother do not (normal pigmentation). Claude’s parents are both normal, but he has a sister who has the condition (is albino). Answer the following questions If Andrea and Claude are carriers for the albino allele, what is the probability that they have an albino child? If Andrea and Claude have a second child, what is the probability this child be normal (non-albino)? NOTE: Draw a punnet square or show your work.
At the beginning of the film, you were introduced to Davaun and Skyy Cooper, who both have sickle cell disease. Which of the following must be true about their parents? Group of answer choices One parent has at least one copy of the sickle cell allele. Both parents have at least one copy of the sickle cell allele. Both parents have sickle cell disease. One parent has sickle cell disease.
Hereditary hemochromatosis is an autosomal recessive genetic disorder that causes the body to absorb too much iron from the diet. This excess iron is stored in the body's tissues and organs, particularly the skin, heart, liver, pancreas, and joints. Because humans cannot increase the excretion of iron, excess iron can overload and eventually damage tissues and organs. Some individuals who are homozygous for this autosomal recessive gene experience only skin discoloration and joint pain, others experience heart disease in addition to the skin discoloration, still other individuals suffer also suffer from diabetes, severe heart disease, and liver damage. Name and define this genetic phenomenon and explain how it relates to this specific genetic situation described above.
Adenike and her partner, Debare, are expecting their first child. Adenike is healthy as are her two sisters but her brother has PKU, a recessive disorder of the PAH gene. Genotypically he must be pah-/pah-. Neither of Adenike's parents has PKU but both of her grandmothers did. Debare is a carrier of Sickle Cell trait, which means he has one allele for wildtype hemoglobin (HbA) and one allele for Sickle Cell (HbS), making him HgA/HbS. More importantly, he has two alleles for Marfan Syndrome, a pleiotropic dominant disorder that can affect up to 30 different traits (M+/M+). No one in Debare's family has ever had PKU and no one in Adenike’s family has ever had Sickle Cell or Marfan Syndrome. They consult a genetics counselor over concern of the health of their baby. The genetics counselor collects the medical histories of three generations; their grandparents, their parents, and them. In her calculations, she produces a phenotypic key that indicates M = Marfan, Hb = sickle cell, and pah-…
Adenike and her partner, Debare, are expecting their first child. Adenike is healthy as are her two sisters but her brother has PKU, a recessive disorder of the PAH gene. Genotypically he must be pah-/pah-. Neither of Adenike's parents has PKU but both of her grandmothers did. Debare is a carrier of Sickle Cell trait, which means he has one allele for wildtype hemoglobin (HbA) and one allele for Sickle Cell (HbS), making him HgA/HbS. More importantly, he has two alleles for Marfan Syndrome, a pleiotropic dominant disorder that can affect up to 30 different traits (M+/M+). No one in Debare's family has ever had PKU and no one in Adenike’s family has ever had Sickle Cell or Marfan Syndrome. They consult a genetics counselor over concern of the health of their baby. The genetics counselor collects the medical histories of three generations; their grandparents, their parents, and them. In her calculations, she produces a phenotypic key that indicates M = Marfan, Hb = sickle cell, and pah-…