Dr. Pradeep Patra, Dr. Virander Chauhan, and their colleagues assessed children in 2,087 villages in the Indian state of Chhattisgarh for their sickle cell anemia genotype. Sickle cell anemia is coded for by the t allele. Individuals who are tt have the more severe illness phenotype of sickle cell disease while Tt individuals have a moderate illness phenotype called sickle cell trait. Individuals who are TT do not have sickle cell anemia. Of the 359,823 children assessed, 33,467 were Tt and only 747 were tt. The remaining 325,609 children were TT. We will use these data to answer the following 6 questions. Calculate the total number of alleles for this gene assessed in the sample of children. DO NOT ROUND.
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- The following is a summary of the possible sickle-cell genotypes and phenotypes: AA - cojmpletely normal AS - sickle-cell trait (this person has a combination of normal hemoglobin and the abnormal, sickled form of hemoglobin) SS - sickle-cell anemia (all abnormal hemoglobin) If both parents and heterozygous for sickle-cell disease, what are the possible genotypes and phenotypes for their children?A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known concordance statistics, would his MZ twin be at high risk for the disease? Would the twins risk decrease if he were raised in an environment different from that of his schizophrenic brother?A research team genotyped hundreds of families affected by haemophilia. Among those families, they found many that had a pattern of RFLP like that of daughter1, her husband and her parents. When they genotyped the children in those families, they found the following association between the RFLP and hemophilia: The numbers at the bottom indicate the number of progeny with that combination of hemophilia phenotype and RFLP polymorphism found among these families. What is the map distance between the RFLP and the hemophilia gene? Show your work.
- Sickle cell anemia is an inheritable red blood cell disorder that results in sickle-shaped red blood cells. The sickle-shaped red blood cells can stick to blood vessel walls and cause a blockage or slow the movement of blood throughout the body. Individuals who are heterozygous produce both normal and sickle-shaped red blood cells which gives them resistance to malaria but they do not develop sickle cell anemia (so heterozygotes are unaffected on the pedigree).Let HbS be the allele for sickle cell anemia and let HbA be the allele for normal red blood cells. Which of the following rows provides the correct genotypes for individuals I-2, I-4, II-1, and III-1? Select one: a. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbA_ b. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbAHbS c. I-2 I-4 II-1 III-1 HbAHbS HbAHbS HbAHbS HbAHbS d. I-2 I-4 II-1 III-1 HbAHbA HbAHbA HbAHbA HbAHbAThe following is a summary of the possible sickle-cell genotypes and phenotypes: AA - cojmpletely normal AS - sickle-cell trait (this person has a combination of normal hemoglobin and the abnormal, sickled form of hemoglobin) SS - sickle-cell anemia (all abnormal hemoglobin) Fill in the punnett square and answer the question: If both parents and heterozygous for sickle-cell disease, what are the possible genotypes and phenotypes for their children?A couple consulted a genetic counselor and they found out the following: Basha: A blood type, blue eye color, normal skin condition, carrier of cystic fibrosis gene, and carrier of hemophilia gene Popoy: B blood type, has brown eye color, normal skin condition, carrier of cystic fibrosis gene and negative to hemophilia. Clues for the table: • Blood Type: The probability that they’ll have an offspring with blood type the same as Popoy is 25% only • Eye Color: The probability that they’ll have an offspring with brown eye color is 75%. • Skin condition: The probability that their offspring will be an albino is 25% What is the probability that the offspring will have/ be: A. a girl with all the same phenotype as her mother. B. 2 girls with neither the blood type of the parents. C. 2 boys with normal skin color and carrier of cystic fibrosis gene; 1 girl with normal skin color and negative to cystic fibrosis. D. 2 girls carrier of both cystic fibrosis gene and hemophilia, a boy † positive…
- Adenike and her partner, Debare, are expecting their first child. Adenike is healthy as are her two sisters but her brother has PKU, a recessive disorder of the PAH gene. Genotypically he must be pah-/pah-. Neither of Adenike's parents has PKU but both of her grandmothers did. Debare is a carrier of Sickle Cell trait, which means he has one allele for wildtype hemoglobin (HbA) and one allele for Sickle Cell (HbS), making him HgA/HbS. More importantly, he has two alleles for Marfan Syndrome, a pleiotropic dominant disorder that can affect up to 30 different traits (M+/M+). No one in Debare's family has ever had PKU and no one in Adenike’s family has ever had Sickle Cell or Marfan Syndrome. They consult a genetics counselor over concern of the health of their baby. The genetics counselor collects the medical histories of three generations; their grandparents, their parents, and them. In her calculations, she produces a phenotypic key that indicates M = Marfan, Hb = sickle cell, and pah-…Adenike and her partner, Debare, are expecting their first child. Adenike is healthy as are her two sisters but her brother has PKU, a recessive disorder of the PAH gene. Genotypically he must be pah-/pah-. Neither of Adenike's parents has PKU but both of her grandmothers did. Debare is a carrier of Sickle Cell trait, which means he has one allele for wildtype hemoglobin (HbA) and one allele for Sickle Cell (HbS), making him HgA/HbS. More importantly, he has two alleles for Marfan Syndrome, a pleiotropic dominant disorder that can affect up to 30 different traits (M+/M+). No one in Debare's family has ever had PKU and no one in Adenike’s family has ever had Sickle Cell or Marfan Syndrome. They consult a genetics counselor over concern of the health of their baby. The genetics counselor collects the medical histories of three generations; their grandparents, their parents, and them. In her calculations, she produces a phenotypic key that indicates M = Marfan, Hb = sickle cell, and pah-…Adenike and her partner, Debare, are expecting their first child. Adenike is healthy as are her two sisters but her brother has PKU, a recessive disorder of the PAH gene. Genotypically he must be pah-/pah-. Neither of Adenike's parents has PKU but both of her grandmothers did. Debare is a carrier of Sickle Cell trait, which means he has one allele for wildtype hemoglobin (HbA) and one allele for Sickle Cell (HbS), making him HgA/HbS. More importantly, he has two alleles for Marfan Syndrome, a pleiotropic dominant disorder that can affect up to 30 different traits (M+/M+). No one in Debare's family has ever had PKU and no one in Adenike’s family has ever had Sickle Cell or Marfan Syndrome. They consult a genetics counselor over concern of the health of their baby. The genetics counselor collects the medical histories of three generations; their grandparents, their parents, and them. In her calculations, she produces a phenotypic key that indicates M = Marfan, Hb = sickle cell, and pah-…
- The following is a summary of the possible sickle-cell genotypes and phenotypes: AA - cojmpletely normal AS - sickle-cell trait (this person has a combination of normal hemoglobin and the abnormal, sickled form of hemoglobin) SS - sickle-cell anemia (all abnormal hemoglobin) Make a punnett square for help answering the question: What is the probability of a couple having a child with sickle-cell trait if one parent is normal and the other has sickle-cell trait?The following is a summary of the possible sickle-cell genotypes and phenotypes: AA - cojmpletely normal AS - sickle-cell trait (this person has a combination of normal hemoglobin and the abnormal, sickled form of hemoglobin) SS - sickle-cell anemia (all abnormal hemoglobin) Make a punnett square for help answering the question: If both parents and heterozygous for sickle-cell disease, what are the possible genotypes and phenotypes for their children?A survey was taken to determine the blood types of children from marriages in which the wife had the blood group AB and the husband had blood type A but one of his parents is type O. The survey resulted in 250 type A, 90 type B, and 110 type AB children. Is the deviation from the expected significant?