In humans, there is a gene called sickle-cell anemia, which produces severe anemia when homozygous recessive. The name of the disease comes from the fact that many red blood cells take on abnormal sickle shape. People homozygous recessive for this trait usually die before adulthood. Heterozygous people appear normal, but when a sample of the blood is held under low oxygen concentration, the red cells take on the sickle shape. A young woman about to be married is concerned about her future children because her brother died of sickle-cell anemia. A sample of her blood sickles under low oxygen concentration, but that red blood of her perspective husband remains normal. What can you say about the woman and the man, and about their future children? HINT: Use Punnett square to help you and receive full credit

In humans, there is a gene called sickle-cell anemia, which produces severe anemia when homozygous recessive. The name of the disease comes from the fact that many red blood cells take on abnormal sickle shape. People homozygous recessive for this trait usually die before adulthood. Heterozygous people appear normal, but when a sample of the blood is held under low oxygen concentration, the red cells take on the sickle shape. A young woman about to be married is concerned about her future children because her brother died of sickle-cell anemia. A sample of her blood sickles under low oxygen concentration, but that red blood of her perspective husband remains normal. What can you say about the woman and the man, and about their future children? HINT: Use Punnett square to help you and receive full credit

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter19: Introduction To Genetics

Section: Chapter Questions

Problem 9CT

See similar textbooks

Similar questions

In humans, there is a gene called sickle-cell anemia, which produces severe anemia when homozygous recessive. The name of the disease comes from the fact that many red blood cells take on abnormal sickle shape. People homozygous recessive for this trait usually die before adulthood. Heterozygous people appear normal, but when a sample of the blood is held under low oxygen concentration, the red cells take on the sickle shape. A young woman about to be married is concerned about her future children because her brother died of sickle-cell anemia. A sample of her blood sickles under low oxygen concentration, but that red blood of her perspective husband remains normal. What can you say about the woman and the man, and about their future children?
The attached image is a pedigree of a family with a history of sickle cell anemia (the individuals with the filled-in symbols have the disease and no new mutations are occurring in any individual). Sickle cell anemia is inherited in an autosomal recessive manner. What is the probability that the individual with the question mark (?) will get the disease? a) 1/4 b) 1/2 c) 2/3 d) 1
Take the example of B-thalassemia, an autosomal recessive genetic disease that particularly affects people from around the Mediterranean. This disease is associated with an anomaly of hemoglobin, a protein essential for the transport of oxygen, which is composed of four chains: two alpha (a) and two beta (B). In case of B-thalassemia, the ẞ chains are produced in insufficient or no quantity in an individual homozygous recessive resulting in insufficient production of overall hemoglobin leading to anemia and other physiological challenges. The gene that controls the synthesis of the ẞ chains is located on chromosome 11. Here is part of the coding portion of this gene (which controls a total of 146 amino acids and of which you only see the portion 36 to 41) and one of the targeted mutations: 1. Give the sequence of amino acids from the template and mutated strands. 2. What type of point mutation is it? 3. Using the principles of the theory of evolution, explain briefly and generally why…
What are the genotypes of the mother and father in the pedigree below? The pedigree shows albinism (an autosomal recessive trait). The shaded shapes represent albino individuals. a. mother - homozygous dominant; father - homozygous dominant b. mother - heterozygous; father - homozygous recessive c. mother - homozygous recessive; father - heterozygous d. mother - heterozygous; father - heterozygous e. mother - homozygous dominant; father - homozygous recessive
In humans, alkaptonuria is a metabolic disorder in which affected persons produce black urine. Alkaptonouria results from an allele (a) that is recessive to the allele for normal metabolism (A). Alana has a normal metabolism, but her brother has alkaptonouria. Alana’s father has alkaptonuria. Give the genotypes of Alana _______, her mother________, her father_______, and her brother______. If Alana’s parents have another child, what is the probability that the child will have alkaptonuria?_____ If Alana marries a man with alkatonuria, what is the probability that their first child will have black urine? _______ What is the probability that 3 of their children will have black urine?__________ If Alana marries a man that does not have alkatonuria, but has a mother that does, then what is the probability that their first child will have black urine? _______ 3 children in a row? ___________
In a particular country in sub-Saharan Africa, a medical study revealed that 0.075% of the country's population are suffering from sickle-cell anemia. Sickle cell disease is caused by a mutation in the haemoglobin-Beta gene found on chromosome 11. Sickle cell anemia is controlled by a pair of alleles, H and h, where the individuals with the illness have the homozygous recessive genotype; those with normal red blood cells have the alternative genotype. Using the Hardy-Weinberg's equation, calculate the percentage of the population of the two genotypes for normal blood cells. In a few remote areas in that country, the percentage of sickle cell anemia reaches as high as 5%. Calculate the percentage of homozygous and heterozygous individuals with the normal blood cells and find the ratio for both phenotypes.
In humans, the genetic disease cystic fibrosis is caused by a recessive allele (a). The normal (healthy) allele is dominant (A). What is the genotype of someone who has cystic fibrosis? What are the two different genotypes that a healthy person could have? If two people were both heterozygous for the cystic fibrosis gene, what fraction of their children would be likely to have this disease? Hint: Draw a Punnett square to figure it out.
In humans, the gene for albinism (a) is recessive to the gene for normal skin pigmentation (A). If two heterozygous persons have children, what is the probability they will have a child who is an albino? What is the probability they will have a child that is a carrier of the recessive gene?
Sickle cell anemia is caused by an individual carrying two recessive copies of the hemoglobin gene (hemoglobin gene is labeled Hb, and the recessive version is Hbs). Thus, to have sickle cell anemia, a person must have the genotype HbSHbS. A person that is HbAHbA carries two copies of the normal hemoglobin gene and does not have sickle cell anemia. A person that is heterozygous (HbAHbS) produces enough normal hemoglobin to not have sickle cell anemia but is also resistant to malaria. People that are heterozygous are called “carriers” because they carry the recessive allele but do not express the recessive phenotype. a. A couple are both resistant to malaria but do not have sickle cell anemia. Draw a Punnett square to represent this cross. b. What is the probability that the couple has three children where one child does not have a recessive allele, one child is resistant to malaria and does not have sickle cell anemia, and one child has sickle cell anemia?
Holstein cattle suffer from the condition citrullinemia, in which homozygous recessive calves die within a week of birth because they cannot break down ammonia that is produced when amino acids are metabolized. If a cow that is heterozygous for the citrullinemia gene is inseminated by a bull that is homozygous dominant, what is the probability that a calf inherits citrullinemia?
For a recessive condition, two normal heterozygous individuals have children. What is the likelihood of their children being affected by this condition? What is the likelihood of their children being carriers without the condition? What is the likelihood of their asymptomatic children being carriers? Suppose that an individual with the condition has children with a heterozygous individual, what is the likelihood of their children being carriers?
Cystic fibrosis is a genetic disease caused by a recessive allele. Two parents without the disease have a child with the disease, indicating they are both heterozygotes. Assuming that the child did not have a mutation giving it the disease, what is the probability that a second child of the same parents would have the disease? Group of answer choices a. 1 b. 0.25 c. 0 d. 0.5