Some older vaccines used a weakened strain of the pathogenic virus in the injection in the hope that the weakened virus would induce an immune response without causing disease. The virus vectors used in genetic engineering have all the harmful virus genes cut out and replaced with the foreign gene, such as one that makes a protein that is absent in the human patient. Which type of viral vaccine would you prefer to take as the safest option? Why?

Biology: The Unity and Diversity of Life (MindTap Course List)
14th Edition
ISBN:9781305073951
Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Chapter15: Studying And Manipulating Genomes
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  • Some older vaccines used a weakened strain of the pathogenic virus in the injection in the hope that the weakened virus would induce an immune response without causing disease. The virus vectors used in genetic engineering have all the harmful virus genes cut out and replaced with the foreign gene, such as one that makes a protein that is absent in the human patient. Which type of viral vaccine would you prefer to take as the safest option? Why?

  • Some Covid 19 vaccines in development use the adenovirus, a common vector used in gene therapies, to inject the mRNa for the spike protein into human muscle cells. Why might vaccines using a virus vector be more likely to need only refrigeration and not deep-cold storage, given what you know about viruses?

     

(a) Lipid vesicle
DNA
Lipid
bilayer
(b) Electroporation
Ne N
Electrical
pulse
410
(e) Biolistic delivery
DNA-coated
particles
(d) Microinjection
(e) Virus infection
Figure 10-20
Introduction to Genetic Analysis, Twelfth Edition
O 2020 W. H. Freeman and Company
Transcribed Image Text:(a) Lipid vesicle DNA Lipid bilayer (b) Electroporation Ne N Electrical pulse 410 (e) Biolistic delivery DNA-coated particles (d) Microinjection (e) Virus infection Figure 10-20 Introduction to Genetic Analysis, Twelfth Edition O 2020 W. H. Freeman and Company
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