Some transcription regulators bind to DNA andcause the double helix to bend at a sharp angle. Such“bending proteins” can affect the initiation of transcrip-tion without directly contacting any other protein. Can youdevise a plausible explanation for how such proteins mightwork to modulate transcription? Draw a diagram that illus-trates your explanation.

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter10: From Proteins To Phenotypes
Section: Chapter Questions
Problem 21QP: Transcriptional regulators are proteins that bind to promoters (the 5-flanking regions of genes) to...
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Some transcription regulators bind to DNA and
cause the double helix to bend at a sharp angle. Such
“bending proteins” can affect the initiation of transcrip-
tion without directly contacting any other protein. Can you
devise a plausible explanation for how such proteins might
work to modulate transcription? Draw a diagram that illus-
trates your explanation.

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