Some Type-II immunopathology mediated autoimmune diseases have manifestations in multiple different organs. Discuss how antibodies to one single antigen can cause damage in multiple sites throughout the body. Things you might discuss include, but are not limited to where the antigen could be expressed, how antibodies are made, how they bind antigen, where they circulate, the ratios of antigen to antibody, mechanisms of the immune system that result in cellular/tissue damage, or how immune system components can affect other organs. You might also comment on what makes one antigen an attractive target rather than another. Please do NOT comment on all the things listed above, they are just to get you thinking. If you are having trouble getting started, it might help to think about a specific disease which affects multiple organs.
Some Type-II immunopathology mediated autoimmune diseases have manifestations in
multiple different organs. Discuss how antibodies to one single antigen can cause damage in
multiple sites throughout the body. Things you might discuss include, but are not limited to
where the antigen could be expressed, how antibodies are made, how they bind antigen,
where they circulate, the ratios of antigen to antibody, mechanisms of the immune system
that result in cellular/tissue damage, or how immune system components can affect other
organs. You might also comment on what makes one antigen an attractive target rather than
another. Please do NOT comment on all the things listed above, they are just to get you
thinking. If you are having trouble getting started, it might help to think about a specific
disease which affects multiple organs.
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