Succinic acid is produced by Actinobacillus succinogenes with the following medium composition (g/L): glucose, 50; yeast extract, 5; NaCl, l; Na2HPO4, 0.3; NaH2PO4, 1.4; K2HPO4, 1.5;

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter21: Heparin Infusion Calculations
Section: Chapter Questions
Problem 1.1P
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Succinic acid is produced by Actinobacillus succinogenes with the following medium composition (g/L):

glucose, 50;

yeast extract, 5;

NaCl, l;

Na2HPO4, 0.3;

NaH2PO4, 1.4;

K2HPO4, 1.5;

MgC12.6H20, 0.2;

CaC12.2H20, 0.23.

The pH is controlled and maintained at 3.63. Estimate the range of upper limit, if 0.8% of deadband is applied. With a schematic diagram, explain how to maintain the pH throughout the fermentation process.

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