what are the possible genotypes for susan and her husband in the following pedigree Pedigree of Sickle Cell Anemia in the Miller FamilySusanHusbandhealthyboyAffected healthygirlgirlAffectedboy

Name: what are the possible genotypes for susan and her husband in the follo
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Description: what are the possible genotypes for susan and her husband in the following pedigree Pedigree of Sickle Cell Anemia in the Miller FamilySusanHusbandhealthyboyAffected healthygirlgirlAffectedboy

Sickle cell anemia is an autosomal genetic disease and it is inherited as an autosomal recessive…

Answered: Susan Husband healthy Affected healthy…

Science

Biology

Susan Husband healthy Affected healthy Affected

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter5: Unit, Percentage, Milliequivalent, Ratio, And Household Measures

Section: Chapter Questions

Problem 2.4P

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Sickle-cell disease (often called sickle-cell anemia) is a disease that is caused by a mutation to the gene that is responsible for producing the protein hemoglobin. Remember that hemoglobin is a protein in the red blood cells which is responsible for carrying oxygen throughout the body. When a person possesses the mutated hemoglobin allele, their red blood cells take on an altered shape and this results in a variety of symptoms ranging from general weakening of the body, damage to the organs and even death. The sickle cell allele is recessive to the healthy allele, thus only individuals that are homozygous for the recessive allele will have sickle-cell disease. Individuals that are homozygous for the healthy allele, along with heterozygous, individuals will be physically healthy. Question: Given that this mutated allele will cause disease and death in individuals, what would you predict to occur to the frequency of this allele in the population? Explain.
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One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood disorder in which red blood cells are abnormally shaped and fragile, leading to a short supply of red blood cells. These abnormal cells can also get stuck in small vessels, which prevent blood flow, leading to fatigue, pain, and other severe complications. Patients with sickle cell anemia produce defective beta-globin due to a point mutation that causes the change of a single amino acid residue. This is an example of what type of mutation? nonsense mutation missense mutation frameshift mutation deletion mutation