Answered: True or False: An individual with…

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Biology

True or False: An individual with sickle-cell anemia is caused by a missense mutation.

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter11: The Blood

Section: Chapter Questions

Problem 5RE

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Concept explainers

Hematology

Hematology is the branch of biology. Hematology is the medical field that deals with the treatment of blood disorders and cancers, such as hemophilia, leukemia, lymphoma, and sickle-cell anemia. Hematologists and hematopathologists are medical professionals who specialize in illnesses of the blood and its components.

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True or False: An individual with sickle-cell anemia is caused by a missense mutation.

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One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood disorder in which red blood cells are abnormally shaped and fragile, leading to a short supply of red blood cells. These abnormal cells can also get stuck in small vessels, which prevent blood flow, leading to fatigue, pain, and other severe complications. Patients with sickle cell anemia produce defective beta-globin due to a point mutation that causes the change of a single amino acid residue. This is an example of what type of mutation? nonsense mutation missense mutation frameshift mutation deletion mutation
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Sickle-cell anemia is a genetic disorder of individuals homozygous for a mutation of hemoglobin that causes their red blood cells to be sickle shaped and stiff under conditions of low pO2. Why is this disease life threatening?