T F T F T F T T F F T F T F Vmax is the velocity observed when all of the enzyme present is fully saturated with substrate; in other words, when [ES] = [E]total. High blood glucose levels are detected by insulin secreting cells of the pancreas initiating a positive feedback loop where insulin secreting cells of the pancreas stimulate the release of insulin into the blood lowering blood glucose levels. Steroids are hormones synthesized from cholesterol. Blood flow in the cardiovascular system is a diffusive process. Paracrine signaling involves exocytosis, diffusion over long distances, and systemic endocytosis in another tissue. At equilibrium d[A]/dt = d[B]/dt = 0 Steroid hormones can bind transcription factors on DNA enhancing transcription.
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- Which of the following statements about the integration of fat and carbohydrate metabolism control is correct? a. High insulin/glucagon ratio activates lipolysis in muscle b. High insulin/glucagon ratio inhibits lipogenesis in liver. c. Low insulin/glucagon ratio activates lipolysis in adipocytes. d. Insulin-dependent glucose transporters are recruited to their functional membrane site when insulin levels are lowThe Km of liver glucokinase is _____ than typical blood glucose concentrations. At typical blood glucose concentrations, therefore, the rate of glucose catabolism in liver cells is relatively ____. Much higher; fast Much higher; slow Much lower; fast Much lower; slowAssume that you want to lose 20 lb of body fat in 60 days. Your present dietary intake is 3000 Cal/ day. What should your caloric intake be, in Cal/day, to achieve this goal, assuming no change in exercise habits?
- When blood glucose levels rise following a meal, the following events occur. Arrange these events in the appropriate sequence.(a) Glucagon is secreted.(b) Glycolysis replenishes ATP supplies.(c) Glucose is absorbed by cells.(d) The liver releases glucose into the bloodstream.(e) Glycogen synthesis (glycogenesis) occurs withexcess glucose.(f) Blood levels pass through normal to below normal(hypoglycemic).(g) Insulin levels rise.Regulation in biological systems depends on feedback .which is an exmple of in formation flow. when diabbetes destroy insulin-producing cells, what infortamtion flow in disrupted? The body is unable to send signals that indicate the amount of sugar in the blood. Cells in the bladder are no longer able to send signals when the blodder fills. Appetite signals no longer regulate feeding . The pancres is unable to produce enzymes to break down protein.In NOT MORE than 350 words, distinguish between the metabolic concepts presented by the terms: i. fed state, ii. fasted state/in-between meals, and iii. extended fasting/starvation. Your response should highlight the energy status of cells under these conditions, preferred fuels, predominant metabolic pathways, and hormonal effects on cellular processes.
- True or false: Consider a liver cell balancing the metabolic allocations under starving conditions. a. ____ Proteins are utilized in glucose production. b. ____ Glycerol molecules are utilized in glucose production. c. ____ Cholesterol molecules are utilized in ATP production. d. ____ Acetyl-CoA molecules are utilized in glucose production.During the FEED cycle, the two major effects of INSULIN on the liver involves ____. Select one: a. glucose consumption (glycolysis and glycogen synthesis), fatty Acid and TAG synthesis b. glucose release and fatty acid synthesis c. TAG and fatty acid degradation d. gluconeogenesis and glycogenolysisWhat are the 3 macronutrients and how do each provide energy to the body? Define the fed, post-absorptive, fasting, and starved states. Outline changes in the utilization of glucose, fatty acids, amino acids, and ketone bodies as the body transitions from the fed state to the prolonged starvation state. Describe the impacts of insulin, glucagon, epinephrine, and cortisol on CHO, lipid, and protein metabolism. Describe the major pathways that occur in the liver, muscle, adipose tissue. Describe which hormones exercise tends to increase and potential impacts on pathways we’ve discussed. Describe the cori cycle and the glucose-alanine cycle. Describe differences in primary fuel sources by exercise intensity. Describe classical vs moderate CHO loading in preparation for competition in trained athletes. Simple to the point answers please!
- In the lead-up to a marathon, runners often load their body with carbohydrates to ensure a constant supply of energy. Create a step by step flow chart to show how carbohydrate loading takes place in the lead up to a marathon. The role of insulin should be clearly included in the flow sequence.The typical human adult uses about 160 g of glucose per day, 120 g of which is used by the brain. The available reserve of glucose (~20 g of circulating glucose and ~190 g of glycogen) is adequate to sustain the individual for about one day. After the reserve has been depleted during starvation, how would the body obtain more glucose?Which of the following is the primary process by which insulin stimulates glucose transport into adipose tissue cells?A) Activating Na+-K+ ATPaseB) Increasing synthesis of the glucose transporterC) Phosphorylating glucose to maintain the gradient of free glucose across the cellD) Promoting movement of the glucose transporter from the cytoplasm to the cell membrane