The absorption of ketoconazole has been shown to be impaired in patients with drug-induced achlorhydria. The drug absorption was increased significantly to approximately 65% when the drug was taken with an acidic beverage such as Coca-Cola (pH 2.5). Ketoconazole is a synthetic azole antifungal agent and a weakly dibasic compound with pKa of 2.9 and 6.5. Using the information provided and the pH partition hypothesis, justify the use of Coca-Cola to improve the absorption of this antifungal agent.
The absorption of ketoconazole has been shown to be impaired in patients with drug-induced achlorhydria. The drug absorption was increased significantly to approximately 65% when the drug was taken with an acidic beverage such as Coca-Cola (pH 2.5). Ketoconazole is a synthetic azole antifungal agent and a weakly dibasic compound with pKa of 2.9 and 6.5. Using the information provided and the pH partition hypothesis, justify the use of Coca-Cola to improve the absorption of this antifungal agent.
Chapter6: Oral Medication Labels And Dosage Calculation
Section: Chapter Questions
Problem 7.1P
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The absorption of ketoconazole has been shown to be impaired in patients with drug-induced
achlorhydria. The drug absorption was increased significantly to approximately 65% when
the drug was taken with an acidic beverage such as Coca-Cola (pH 2.5). Ketoconazole is a
synthetic azole antifungal agent and a weakly dibasic compound with pKa of 2.9 and 6.5.
Using the information provided and the pH partition hypothesis, justify the use of Coca-Cola to
improve the absorption of this antifungal agent.
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