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Describe the biosynthesis of acetylcholine in cholinergic neurons
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- Briefly describe where a cholinergic drug acts and how itaffects the postsynaptic receptors. Give two examples ofits possible effects on function.In cholinergic neurotransmission, inhibition of the choline transporter will affect the normal synthesis and release acetylcholineTRUE OR FALSEIdentify the targets of the cholinergic and adrenergic neurotransmitters of the ANS.
- Briefly describe how silent glutamatergic synapses become activated during long term potentiation, describing all of the key neurotransmitters and their post-synaptic receptors and events that give rise to the process.Under anesthesia, acetylcholinesterase inhibitors can be given in combination with blockade of muscarinic receptors. Explain the purpose of the two treatments.You measure subregion-specific release of GABA in the basal ganglia. Give two regions where you would expect to find the release of GABA neurotransmitter.
- Explain how the binding of heroin to presynaptic neurones raises the probability of action potentials in the postsynaptic neurone. asap typed onlyExplain how the signal transmission at a synapse in an individual with Parkinson's disease is different than an unaffected individual. List the steps involved in an action potential moving from the axon terminal of the pre-synaptic neuron to the dendrites of the post-synaptic neuron. Explain how the process is different in individuals affected with Parkinson's disease.Explain how monoamines are inactivated at the synapse and how this process can be clinically manipulated.
- Chemical transmitters in basal ganglia include all the following, except :-a- GABAb- Dopaminec- Glutamated- GlycineExplain how inhibition can be produced by (a) muscarinic ACh receptors in the heart; and (b) GABAreceptors in neurons of the CNS.How will you classify these drugs, cholinergic agonists or antagonists? Why?